TY - JOUR T1 - The Effects of Ascorbic Acid and U-74389G on Renal Ischemia-Reperfusion Injury in a Rat Model JF - In Vivo JO - In Vivo SP - 2475 LP - 2484 DO - 10.21873/invivo.12063 VL - 34 IS - 5 AU - CONSTANTINOS G. ZOGRAFOS AU - DIMOSTHENIS CHRYSIKOS AU - THEODOROS PITTARAS AU - VASILEIOS KARAMPELIAS AU - AIKATERINI CHAIRAKAKIS AU - ANTONIS GALANOS AU - IOANNIS SFINIADAKIS AU - EVANGELOS FELEKOURAS AU - GEORGE C. ZOGRAFOS AU - MICHAIL SIDERIS AU - KONSTANTINA PAPADOPOULOU AU - APOSTOLOS E. PAPALOIS Y1 - 2020/09/01 UR - http://iv.iiarjournals.org/content/34/5/2475.abstract N2 - Background/Aim: U-74389G and ascorbic acid protect the cells from oxidation. This study aimed to depict their role in ischemia–reperfusion injury in a renal rat model. Materials and Methods: Sixty Wistars rats were randomized into six groups of 10 animals each. Group A Ischemia 30 min, reperfusion 60 min; Group B Ischemia 30 min, reperfusion 120 min; Group C Ischemia 30 min, ascorbic acid administration, reperfusion 60 min; Group D Ischemia 30 min, ascorbic acid administration, reperfusion 120 min; Group E Ischemia 30 min, U-74389G administration, reperfusion 60 min; Group F Ischemia 30 min, U-74389G administration, reperfusion 120 min. We then collected tissue and blood samples. Results: Histology and the significantly decreased malondialdehyde and tumor necrosis factor-α levels indicated that ascorbic acid was superior to U-74389G, at pre-defined time intervals. Conclusion: Ascorbic acid and U-74389G ameliorated renal damage induced by ischemia–reperfusion injury, suggesting a therapeutic effect. ER -