%0 Journal Article %A SAHIN YUCELI %A GULCE NAZ YAZICI %A RENAD MAMMADOV %A HALIS SULEYMAN %A MUSTAFA KAYA %A SELCUK OZDOGAN %T The Effect of Rutin on Experimental Traumatic Brain Injury and Edema in Rats %D 2020 %R 10.21873/invivo.12060 %J In Vivo %P 2453-2460 %V 34 %N 5 %X Background/Aim: The aim of the study was to evaluate the effect of rutin, which is a vitamin P1 flavonoid with anti-inflammatory and anti-edema effects, on traumatic brain injury (TBI) and edema in rats. Materials and Methods: Rats were divided into 3 groups as sham group without brain trauma (SG), brain trauma without medication (BT) group and Rutin treated brain trauma (RBT) group. Fifty mg/kg rutin was administered to the RBT group once a day for three days. On the fourth day, rats were sacrificed. Extracted brain tissues were examined biochemically and histopathologically. Results: We found that the levels of malondialdehyde, nuclear factor-kappa B and tumor necrosis factor-alpha decreased, and those of total glutathione increased significantly. Furthermore, rutin administration reduced pyramidal neuron degeneration and poly-morpho-nuclear-leucocyte accumulation due to trauma in brain tissue, while eliminating edema. Conclusion: Rutin might be effective in the treatment of TBI and TBI-related brain edema. %U https://iv.iiarjournals.org/content/invivo/34/5/2453.full.pdf