RT Journal Article SR Electronic T1 Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy via Suppression of Atrogin-1 JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 2345 OP 2351 DO 10.21873/invivo.12047 VO 34 IS 5 A1 AKI MIYAWAKI A1 THIRA ROJASAWASTHIEN A1 SUZURO HITOMI A1 YOSHINORI AOKI A1 MARIKO URATA A1 ASAKO INOUE A1 TAKUMA MATSUBARA A1 KAZUMASA MORIKAWA A1 MANABU HABU A1 KAZUHIRO TOMINAGA A1 SHOICHIRO KOKABU YR 2020 UL http://iv.iiarjournals.org/content/34/5/2345.abstract AB Background/Aim: Geranylgeraniol (GGOH), a C20 isoprenoid naturally occurs in several foods. We previously reported that GGOH treatment reduced the expression levels of Atrogin-1 which is involved in skeletal muscle degradation and stimulates the myogenic differentiation of C2C12 myoblasts. However, the effect of GGOH supplementation on skeletal muscle metabolism in vivo is unknown. Materials and Methods: Skeletal muscle atrophy was induced by denervation. The expression levels of Atrogin-1 were assessed by western blotting or real time PCR. Results: Intraoral administration of GGOH reduced the decrease in the cross-sectional area of muscle fibers and also suppressed the expression levels of Atrogin-1 in denervation induced muscle atrophy. Also, GGOH treatment suppressed the expression of Atrogin-1 and the decrease in skeletal muscle fiber size by glucocorticoid in vitro. Conclusion: Intraoral administration of GGOH rescues denervation-induced muscle atrophy via suppression of Atrogin-1.