TY - JOUR T1 - Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy <em>via</em> Suppression of Atrogin-1 JF - In Vivo JO - In Vivo SP - 2345 LP - 2351 DO - 10.21873/invivo.12047 VL - 34 IS - 5 AU - AKI MIYAWAKI AU - THIRA ROJASAWASTHIEN AU - SUZURO HITOMI AU - YOSHINORI AOKI AU - MARIKO URATA AU - ASAKO INOUE AU - TAKUMA MATSUBARA AU - KAZUMASA MORIKAWA AU - MANABU HABU AU - KAZUHIRO TOMINAGA AU - SHOICHIRO KOKABU Y1 - 2020/09/01 UR - http://iv.iiarjournals.org/content/34/5/2345.abstract N2 - Background/Aim: Geranylgeraniol (GGOH), a C20 isoprenoid naturally occurs in several foods. We previously reported that GGOH treatment reduced the expression levels of Atrogin-1 which is involved in skeletal muscle degradation and stimulates the myogenic differentiation of C2C12 myoblasts. However, the effect of GGOH supplementation on skeletal muscle metabolism in vivo is unknown. Materials and Methods: Skeletal muscle atrophy was induced by denervation. The expression levels of Atrogin-1 were assessed by western blotting or real time PCR. Results: Intraoral administration of GGOH reduced the decrease in the cross-sectional area of muscle fibers and also suppressed the expression levels of Atrogin-1 in denervation induced muscle atrophy. Also, GGOH treatment suppressed the expression of Atrogin-1 and the decrease in skeletal muscle fiber size by glucocorticoid in vitro. Conclusion: Intraoral administration of GGOH rescues denervation-induced muscle atrophy via suppression of Atrogin-1. ER -