PT  - JOURNAL ARTICLE
AU  - JASPAR WITTELER
AU  - TROELS W. KJAER
AU  - SOEREN TVILSTED
AU  - STEVEN E. SCHILD
AU  - DIRK RADES
TI  - Pre-Treatment Seizures in Patients With 1-3 Cerebral Metastases Receiving Local Therapies Plus Whole-brain Radiotherapy
AID  - 10.21873/invivo.12094
DP  - 2020 Sep 01
TA  - In Vivo
PG  - 2727--2731
VI  - 34
IP  - 5
4099  - http://iv.iiarjournals.org/content/34/5/2727.short
4100  - http://iv.iiarjournals.org/content/34/5/2727.full
SO  - In Vivo2020 Sep 01; 34
AB  - Background/Aim: Seizures impair patients' quality of life. The prognostic role of pre-treatment seizures in patients with 1-3 cerebral metastases receiving local therapies plus whole-brain radiotherapy (WBRT) was investigated. Patients and Methods: In 249 patients, prevalence, risk factors and associations of pre-treatment seizures with survival were retrospectively evaluated. Age, gender, performance score, tumor type, number of lesions, extra-cerebral metastases, and time from tumor diagnosis to treatment of cerebral metastasis were analyzed for associations with seizures. These characteristics and pre-treatment seizures were also analyzed for associations with survival. Results: The prevalence of pre-treatment seizures was 24.1%. Trends for associations were found between seizures and gender or performance score. On multivariate analysis, age (p=0.008), performance score (p=0.004), tumor type (p<0.001) and extra-cerebral metastasis (p<0.001) were significantly associated with survival. Conclusion: Seizures were comparably common prior to local therapies plus WBRT for cerebral metastases. No factor was found to be significantly associated with seizures, and seizures were not associated with survival.