PT  - JOURNAL ARTICLE
AU  - TAKEDA, SEIICHI
AU  - TODA, TAKAO
AU  - NAKAMURA, KAZUKI
TI  - Effects of Medium Molecular Weight Heparinyl Phenylalanine on Type I Hypersensitivity
AID  - 10.21873/invivo.11438
DP  - 2019 Jan 01
TA  - In Vivo
PG  - 53--55
VI  - 33
IP  - 1
4099  - http://iv.iiarjournals.org/content/33/1/53.short
4100  - http://iv.iiarjournals.org/content/33/1/53.full
SO  - In Vivo2019 Jan 01; 33
AB  - Background/Aim: We investigated the inhibitory action of medium molecular weight heparinyl phenylalanine (MHF) on type I hypersensitivity in comparison with medium molecular weight heparinyl arginine (MHR). Materials and Methods: MHF and MHR were synthesized from heparin (HE) to decrease the side-effect of HE based on its anticoagulant action and used in this study. Results: MHF demonstrated a significant inhibitory action on 48-h homologous passive cutaneous anaphylaxis in rats. Although MHF did not affect the death of mice injected with a lethal dose of histamine, it significantly prolonged the survival time of mice administered a lethal dose of compound 48/80. On the other hand, MHR did not inhibit type I hypersensitivity. Conclusion: The inhibitory action of MHF on the type I allergic reaction was due to a reduction or delay in histamine release from mast cells. MHF may be a potent anti-allergic agent.