RT Journal Article
SR Electronic
T1 Total Skin Electron Beam Therapy with Rotary Dual Technique as Palliative Treatment for Mycosis Fungoides
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 517
OP 522
VO 32
IS 3
A1 PIOTROWSKI, TOMASZ
A1 FUNDOWICZ, MAGDALENA
A1 PAWLACZYK, MARIOLA
YR 2018
UL http://iv.iiarjournals.org/content/32/3/517.abstract
AB Background/Aim: The aim of the study was to retrospectively assess the efficacy and toxicity of total skin electron beam therapy (TSEBT) in patients with primary cutaneous T-cell lymphoma (MF, mycosis fungoides) at various stages of development. Patients and Methods: Treatment results of 40 patients with MF stage IB-III, treated between 2001 and 2015, were reviewed. Median total dose was 32 Gy, delivered to the entire skin surface. Median follow-up was 60 months. Results: Clinical complete response was documented in 29 and partial response in 11 patients. The clinical response significantly influenced overall survival (OS) (p=0.002) and progression-free survival (PFS) (p<0.001). Mean OS was 76 months. Mean PFS was 48.9 months and current one- and two-year PFS were 67.5% and 55%, respectively. A statistically significant correlation was found between partial and total remission time and stages of the lymphoma (p=0.015). Conclusion: TSEBT is an efficient and well-tolerated palliative treatment for symptomatic primary cutaneous T-cell lymphoma.