TY - JOUR T1 - Association Between HMGB1 and Thrombogenesis in a Hyperlipaemia-induced Microminipig Model of Atherosclerosis JF - In Vivo JO - In Vivo SP - 1871 LP - 1874 DO - 10.21873/invivo.11982 VL - 34 IS - 4 AU - SATORU KAKE AU - HIROAKI KAWAGUCHI AU - TOMOKA NAGASATO AU - TOMONOBU YAMADA AU - TAKASHI ITO AU - IKURO MARUYAMA AU - NAOKI MIURA AU - AKIHIDE TANIMOTO Y1 - 2020/07/01 UR - http://iv.iiarjournals.org/content/34/4/1871.abstract N2 - Background/Aim: An appropriate animal model is essential to investigate the relationship between inflammation, atherosclerosis, and thrombogenesis, and the development of preventive measures and therapies for atherosclerosis. Materials and Methods: Atherosclerosis was induced in Microminipigs (MMPs) using a high-fat diet. We assessed high mobility group box 1 (HMGB1) expression levels and measured thrombus formation using a Total Thrombus Formation Analysis System (T-TAS). MMPs were divided into a normal diet (control) group and four high-fat diet groups, with differing amounts of cholesterol. After 8 weeks, blood was collected for analysis. Results: HMGB1 levels increased with increasing dietary cholesterol, and a negative correlation was found between HMGB1 levels and thrombus formation time. Conclusion: T-TAS is useful in the assessment of thrombogenesis in MMPs and HMGB1 is associated with thrombus formation. ER -