@article {KAKE1871, author = {SATORU KAKE and HIROAKI KAWAGUCHI and TOMOKA NAGASATO and TOMONOBU YAMADA and TAKASHI ITO and IKURO MARUYAMA and NAOKI MIURA and AKIHIDE TANIMOTO}, title = {Association Between HMGB1 and Thrombogenesis in a Hyperlipaemia-induced Microminipig Model of Atherosclerosis}, volume = {34}, number = {4}, pages = {1871--1874}, year = {2020}, doi = {10.21873/invivo.11982}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: An appropriate animal model is essential to investigate the relationship between inflammation, atherosclerosis, and thrombogenesis, and the development of preventive measures and therapies for atherosclerosis. Materials and Methods: Atherosclerosis was induced in Microminipigs (MMPs) using a high-fat diet. We assessed high mobility group box 1 (HMGB1) expression levels and measured thrombus formation using a Total Thrombus Formation Analysis System (T-TAS). MMPs were divided into a normal diet (control) group and four high-fat diet groups, with differing amounts of cholesterol. After 8 weeks, blood was collected for analysis. Results: HMGB1 levels increased with increasing dietary cholesterol, and a negative correlation was found between HMGB1 levels and thrombus formation time. Conclusion: T-TAS is useful in the assessment of thrombogenesis in MMPs and HMGB1 is associated with thrombus formation.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/34/4/1871}, eprint = {https://iv.iiarjournals.org/content/34/4/1871.full.pdf}, journal = {In Vivo} }