RT Journal Article
SR Electronic
T1 Microsatellite Instability Correlated Inflammatory Markers and their Prognostic Value in the Rectal Cancer Following Neoadjuvant Chemoradiotherapy: A Hypothesis-generating Study
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2119
OP 2126
DO 10.21873/invivo.12017
VO 34
IS 4
A1 JOO HO LEE
A1 BYUNG-HEE KANG
A1 CHANGHOON SONG
A1 SUNG-BUM KANG
A1 HYE SEUNG LEE
A1 KEUN-WOOK LEE
A1 EUI KYU CHIE
A1 JAE-SUNG KIM
YR 2020
UL http://iv.iiarjournals.org/content/34/4/2119.abstract
AB Background/Aim: This study aimed to analyze the correlation between microsatellite instability (MSI) and inflammatory markers during neoadjuvant CRT in rectal cancer and its influence on prognosis. Patients and Methods: A total of 549 patients with locally advanced rectal cancer underwent neoadjuvant CRT. Complete blood counts before CRT, and 4-8 weeks after CRT were used to measure neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Results: MSI was significantly associated with elevated NLR and PLR after CRT as well as with a change in NLR and PLR during CRT. Neither inflammatory markers nor MSI significantly related to survival. However, in patients with MSI, an increase in NLR and PLR before CRT was significantly correlated with poor overall survival and disease-free survival. Conclusion: There is correlation between inflammatory markers and MSI during CRT and it influences prognosis. Therefore, inflammatory markers might have a role in assessing the microenvironment related to MSI and the immunologic response in rectal cancer.