%0 Journal Article %A TAKESHI NUMATA %A TAKEO ENDO %A HIDETOSHI YANAI %A KYOKO OTA %A YUSUKE YAMAMOTO %A KEI SHIMIZU %A HIDEYASU YAMADA %A KENJI HAYASHIHARA %A SHINICHIRO OKAUCHI %A HIROAKI SATOH %A YUTAKA YAMADA %A TOMOHIRO TAMURA %A KAZUTO SAITO %A NORIHIRO KIKUCHI %A KOICHI KURISHIMA %A HIROICHI ISHIKAWA %A HIROKO WATANABE %A TOSHIHIRO SHIOZAWA %A NOBUYUKI HIZAWA %A YASUNORI FUNAYAMA %A SHIGEN HAYASHI %A HIROYUKI NAKAMURA %A TAKAAKI YAMASHITA %T Serum CEA and CYFRA Levels in ALK-rearranged NSCLC Patients: Correlation With Distant Metastasis %D 2020 %R 10.21873/invivo.12013 %J In Vivo %P 2095-2100 %V 34 %N 4 %X Aim: To clarify the correlation between serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) and metastasis and survival in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) patients. Patients and Methods: CEA and CYFRA levels in 131 ALK-rearranged NSCLC patients were determined using fluorescence in situ hybridization (FISH), real time-reverse transcription polymerase chain reaction, and immunohistochemistry, using biopsy specimens, cytology specimens, and plasma specimens. Cut-off value of each marker was determined as 10 ng/ml. Results: In logistic regression analysis, higher levels of both markers had a positive relationship with bone metastases, and higher levels of CYFRA was relevant to liver metastases, and multiple-organ metastases. However, these markers were not proven to be poor prognostic factors in Cox's proportional model analysis. Conclusion: Elevated serum CEA and CYFRA levels seem to provide useful clinical information about presence of bone and liver metastasis and multiple-organ metastases, although they were not a powerful indicator of prognosis. These two markers may suggest the extension of metastasis and would be helpful in considering treatment options. %U https://iv.iiarjournals.org/content/invivo/34/4/2095.full.pdf