@article {NUMATA2095, author = {TAKESHI NUMATA and TAKEO ENDO and HIDETOSHI YANAI and KYOKO OTA and YUSUKE YAMAMOTO and KEI SHIMIZU and HIDEYASU YAMADA and KENJI HAYASHIHARA and SHINICHIRO OKAUCHI and HIROAKI SATOH and YUTAKA YAMADA and TOMOHIRO TAMURA and KAZUTO SAITO and NORIHIRO KIKUCHI and KOICHI KURISHIMA and HIROICHI ISHIKAWA and HIROKO WATANABE and TOSHIHIRO SHIOZAWA and NOBUYUKI HIZAWA and YASUNORI FUNAYAMA and SHIGEN HAYASHI and HIROYUKI NAKAMURA and TAKAAKI YAMASHITA}, title = {Serum CEA and CYFRA Levels in ALK-rearranged NSCLC Patients: Correlation With Distant Metastasis}, volume = {34}, number = {4}, pages = {2095--2100}, year = {2020}, doi = {10.21873/invivo.12013}, publisher = {International Institute of Anticancer Research}, abstract = {Aim: To clarify the correlation between serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) and metastasis and survival in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) patients. Patients and Methods: CEA and CYFRA levels in 131 ALK-rearranged NSCLC patients were determined using fluorescence in situ hybridization (FISH), real time-reverse transcription polymerase chain reaction, and immunohistochemistry, using biopsy specimens, cytology specimens, and plasma specimens. Cut-off value of each marker was determined as 10 ng/ml. Results: In logistic regression analysis, higher levels of both markers had a positive relationship with bone metastases, and higher levels of CYFRA was relevant to liver metastases, and multiple-organ metastases. However, these markers were not proven to be poor prognostic factors in Cox{\textquoteright}s proportional model analysis. Conclusion: Elevated serum CEA and CYFRA levels seem to provide useful clinical information about presence of bone and liver metastasis and multiple-organ metastases, although they were not a powerful indicator of prognosis. These two markers may suggest the extension of metastasis and would be helpful in considering treatment options.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/34/4/2095}, eprint = {https://iv.iiarjournals.org/content/34/4/2095.full.pdf}, journal = {In Vivo} }