RT Journal Article SR Electronic T1 The In Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 1789 OP 1796 DO 10.21873/invivo.11973 VO 34 IS 4 A1 YU-SHAN CHEN A1 ROU SUN A1 WEI-LUNG CHEN A1 YU-CHEN YAU A1 FEI-TING HSU A1 JING-GUNG CHUNG A1 CHIA-JUNG TSAI A1 CHIA-LING HSIEH A1 YING-MING CHIU A1 JIANN-HWA CHEN YR 2020 UL http://iv.iiarjournals.org/content/34/4/1789.abstract AB Background/Aim: Radiation (RT) induced ERK/NF-κB in hepatocellular carcinoma (HCC) has been reported in our previous works; it weakens the toxicity of RT or triggers a radioresistance effect. Thus, combining RT with a suitable NF-κB inhibitor may sensitize HCC to RT. Magnolol, a bioactive compound, was known to have anti-inflammatory and anti-tumor functions. Here, we aimed to investigate whether magnolol may enhance anti-HCC efficacy of RT in vivo. Materials and Methods: We established a Hep3B bearing mouse to evaluate the efficacy of the combination treatment of magnolol and RT. Results: Most significantly, tumor volume and tumor weight inhibition was found in the combination group. Tumor immunohistochemistry staining also illustrated the suppression of RT-induced ERK/NF-κB-related proteins expression by magnolol. In addition, intrinsic apoptosis-related proteins, such as caspase-3 and -9, were markedly increased in the combination group. Conclusion: Magnolol may effectively enhance anti-HCC ability of RT by downregulating the expression of ERK/NF-κB-related proteins and increasing the expression of apoptosis-related proteins.