TY - JOUR T1 - The <em>In Vivo</em> Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma JF - In Vivo JO - In Vivo SP - 1789 LP - 1796 DO - 10.21873/invivo.11973 VL - 34 IS - 4 AU - YU-SHAN CHEN AU - ROU SUN AU - WEI-LUNG CHEN AU - YU-CHEN YAU AU - FEI-TING HSU AU - JING-GUNG CHUNG AU - CHIA-JUNG TSAI AU - CHIA-LING HSIEH AU - YING-MING CHIU AU - JIANN-HWA CHEN Y1 - 2020/07/01 UR - http://iv.iiarjournals.org/content/34/4/1789.abstract N2 - Background/Aim: Radiation (RT) induced ERK/NF-κB in hepatocellular carcinoma (HCC) has been reported in our previous works; it weakens the toxicity of RT or triggers a radioresistance effect. Thus, combining RT with a suitable NF-κB inhibitor may sensitize HCC to RT. Magnolol, a bioactive compound, was known to have anti-inflammatory and anti-tumor functions. Here, we aimed to investigate whether magnolol may enhance anti-HCC efficacy of RT in vivo. Materials and Methods: We established a Hep3B bearing mouse to evaluate the efficacy of the combination treatment of magnolol and RT. Results: Most significantly, tumor volume and tumor weight inhibition was found in the combination group. Tumor immunohistochemistry staining also illustrated the suppression of RT-induced ERK/NF-κB-related proteins expression by magnolol. In addition, intrinsic apoptosis-related proteins, such as caspase-3 and -9, were markedly increased in the combination group. Conclusion: Magnolol may effectively enhance anti-HCC ability of RT by downregulating the expression of ERK/NF-κB-related proteins and increasing the expression of apoptosis-related proteins. ER -