PT  - JOURNAL ARTICLE
AU  - AOYAMA, TORU
AU  - ATSUMI, YOSUKE
AU  - KAWAHARA, SHINNOSUKE
AU  - TAMAGAWA, HIROSHI
AU  - TAMAGAWA, AYAKO
AU  - MAEZAWA, YUKIO
AU  - KANO, KAZUKI
AU  - MURAKAWA, MASAAKI
AU  - KAZAMA, KEISUKE
AU  - NUMATA, MASAKATSU
AU  - OSHIMA, TAKASHI
AU  - YUKAWA, NORIO
AU  - MASUDA, MUNETAKA
AU  - RINO, YASUSHI
TI  - The Number of Harvested LNs Is an Independent Prognostic Factor in Lymph Node Metastasis-negative Patients Who Received Curative Esophagectomy
AID  - 10.21873/invivo.12001
DP  - 2020 Jul 01
TA  - In Vivo
PG  - 2021--2027
VI  - 34
IP  - 4
4099  - http://iv.iiarjournals.org/content/34/4/2021.short
4100  - http://iv.iiarjournals.org/content/34/4/2021.full
SO  - In Vivo2020 Jul 01; 34
AB  - Background/Aim: The aim of the present study was to evaluate the optimal number of harvested LNs (LNs) in patients who were LN metastasis-negative after curative esophagectomy for esophageal cancer. Patients and Methods: Sixty-one patients who underwent curative surgery for esophageal cancer between 2005 and 2017 and diagnosed as lymph node metastasis-negative were included in this study. Results: The 5-year overall survival rates were 27.8% for 0-20 harvested LNs, 35.7% for 21-30 harvested LNs, 79.4% for 31-40 harvested LNs, and 85.2% for ≥41 harvested LNs. Thirty harvested LNs was regarded as the optimal critical point of classification, considering the 5-year OS rate. The number of harvested LNs was selected as a significant prognostic factor in both univariate and multivariate analyses. The respective 3- and 5-year OS rates were 50.3% and 36.7% for <30 harvested LNs and 82.4% and 82.4% for ≥30 harvested LNs (p=0.003). Conclusion: Thirty or more harvested LNs was a significant prognostic factor in patients with metastasis-negative LNs after curative esophagectomy for esophageal cancer. Therefore, the number of harvested LNs might be useful for predicting the LN metastasis status in esophageal cancer.