RT Journal Article
SR Electronic
T1 Prognostic Significance of Histological Subtype in Soft Tissue Sarcoma With Distant Metastasis
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1975
OP 1980
DO 10.21873/invivo.11994
VO 34
IS 4
A1 HIROYUKI TSUCHIE
A1 MAKOTO EMORI
A1 NAOHISA MIYAKOSHI
A1 HIROYUKI NAGASAWA
A1 KYOJI OKADA
A1 YASUTAKA MURAHASHI
A1 EMI MIZUSHIMA
A1 JUNYA SHIMIZU
A1 TOSHIHIKO YAMASHITA
A1 YOICHI SHIMADA
YR 2020
UL http://iv.iiarjournals.org/content/34/4/1975.abstract
AB Background/Aim: Few studies have examined the prognostic significance of histological subtypes in patients with soft tissue sarcoma (STS) and distant metastasis, and we evaluated the relationship between the histological subtypes and clinical outcomes. Patients and Methods: This retrospective study evaluated the histological subtypes of 105 patients with STS and distant metastasis. The STS histological subtypes were compared based on the clinical information. Results: The Kaplan-Meier curves for overall survival revealed that myxoid liposarcoma had a significantly better prognosis compared to Malignant Peripheral Nerve Sheath Tumor (MPNST) (p=0.0221). In the multivariate logistic regression analyses, the independent predictors of a poor prognosis were: i) large size, ii) advanced stage, and iii) non-surgical treatment for metastasis (p<0.05). The presence or absence of lung metastasis was not significantly associated with prognosis (p=0.4452). Conclusion: Myxoid liposarcoma had a better prognosis compared to MPNST in STS patients with distant metastasis. The surgical removal of distant metastatic lesions may improve the patient's prognosis.