PT  - JOURNAL ARTICLE
AU  - HIROYUKI TSUCHIE
AU  - MAKOTO EMORI
AU  - NAOHISA MIYAKOSHI
AU  - HIROYUKI NAGASAWA
AU  - KYOJI OKADA
AU  - YASUTAKA MURAHASHI
AU  - EMI MIZUSHIMA
AU  - JUNYA SHIMIZU
AU  - TOSHIHIKO YAMASHITA
AU  - YOICHI SHIMADA
TI  - Prognostic Significance of Histological Subtype in Soft Tissue Sarcoma With Distant Metastasis
AID  - 10.21873/invivo.11994
DP  - 2020 Jul 01
TA  - In Vivo
PG  - 1975--1980
VI  - 34
IP  - 4
4099  - http://iv.iiarjournals.org/content/34/4/1975.short
4100  - http://iv.iiarjournals.org/content/34/4/1975.full
SO  - In Vivo2020 Jul 01; 34
AB  - Background/Aim: Few studies have examined the prognostic significance of histological subtypes in patients with soft tissue sarcoma (STS) and distant metastasis, and we evaluated the relationship between the histological subtypes and clinical outcomes. Patients and Methods: This retrospective study evaluated the histological subtypes of 105 patients with STS and distant metastasis. The STS histological subtypes were compared based on the clinical information. Results: The Kaplan-Meier curves for overall survival revealed that myxoid liposarcoma had a significantly better prognosis compared to Malignant Peripheral Nerve Sheath Tumor (MPNST) (p=0.0221). In the multivariate logistic regression analyses, the independent predictors of a poor prognosis were: i) large size, ii) advanced stage, and iii) non-surgical treatment for metastasis (p<0.05). The presence or absence of lung metastasis was not significantly associated with prognosis (p=0.4452). Conclusion: Myxoid liposarcoma had a better prognosis compared to MPNST in STS patients with distant metastasis. The surgical removal of distant metastatic lesions may improve the patient's prognosis.