RT Journal Article
SR Electronic
T1 Pleural Neutrophil-to-Lymphocyte Ratio May Be Associated With Early Disease Progression in Stage IV Non-small Cell Lung Cancer
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2179
OP 2185
DO 10.21873/invivo.12027
VO 34
IS 4
A1 JEONG UK LIM
A1 CHANG DONG YEO
A1 HYUNG WOO KIM
A1 HYE SEON KANG
A1 CHAN KWON PARK
A1 JU SANG KIM
A1 JIN WOO KIM
A1 SEUNG JOON KIM
A1 SANG HAAK LEE
YR 2020
UL http://iv.iiarjournals.org/content/34/4/2179.abstract
AB Background/Aim: While blood neutrophil-to-lymphocyte ratio (NLR) has been associated with poor prognosis in NSCLC, however few studies have focused on pleural fluid white blood cell differential count. We conducted a retrospective multicenter cohort study to evaluate the predictive value of pleural NLR in non-small cell lung cancer (NSCLC) patients with malignant pleural effusion (MPE). Patients and Methods: From the multicenter lung cancer cohort, 134 epidermal growth factor receptor (EGFR) wild-type patients with NSCLC were selected for evaluation. Receiver operating characteristic (ROC) curve analysis was performed for pretreatment pleural NLR to determine the cut-off value for predicting disease progression within 100 days after the diagnosis. Results: The low-pleural NLR group showed significantly longer overall survival (OS) and progression free survival (PFS) compared to the high-pleural NLR group. After stratification using quartile cut-off values of pleural NLR, the correlation between risk of disease progression and pleural NLR was shown to be dose-dependent. The multivariate analysis on PFS showed that high-pleural NLR (p=0.004) was an independent predictor for shorter PFS with HR of 1.036 (1.011-1.061). Conclusion: Increased pleural NLR is predictive of early disease progression in EGFR mutation wild-type NSCLC patients with MPE.