@article {LIM2179, author = {JEONG UK LIM and CHANG DONG YEO and HYUNG WOO KIM and HYE SEON KANG and CHAN KWON PARK and JU SANG KIM and JIN WOO KIM and SEUNG JOON KIM and SANG HAAK LEE}, title = {Pleural Neutrophil-to-Lymphocyte Ratio May Be Associated With Early Disease Progression in Stage IV Non-small Cell Lung Cancer}, volume = {34}, number = {4}, pages = {2179--2185}, year = {2020}, doi = {10.21873/invivo.12027}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: While blood neutrophil-to-lymphocyte ratio (NLR) has been associated with poor prognosis in NSCLC, however few studies have focused on pleural fluid white blood cell differential count. We conducted a retrospective multicenter cohort study to evaluate the predictive value of pleural NLR in non-small cell lung cancer (NSCLC) patients with malignant pleural effusion (MPE). Patients and Methods: From the multicenter lung cancer cohort, 134 epidermal growth factor receptor (EGFR) wild-type patients with NSCLC were selected for evaluation. Receiver operating characteristic (ROC) curve analysis was performed for pretreatment pleural NLR to determine the cut-off value for predicting disease progression within 100 days after the diagnosis. Results: The low-pleural NLR group showed significantly longer overall survival (OS) and progression free survival (PFS) compared to the high-pleural NLR group. After stratification using quartile cut-off values of pleural NLR, the correlation between risk of disease progression and pleural NLR was shown to be dose-dependent. The multivariate analysis on PFS showed that high-pleural NLR (p=0.004) was an independent predictor for shorter PFS with HR of 1.036 (1.011-1.061). Conclusion: Increased pleural NLR is predictive of early disease progression in EGFR mutation wild-type NSCLC patients with MPE.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/34/4/2179}, eprint = {https://iv.iiarjournals.org/content/34/4/2179.full.pdf}, journal = {In Vivo} }