TY - JOUR T1 - Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications JF - In Vivo JO - In Vivo SP - 1589 LP - 1592 DO - 10.21873/invivo.11947 VL - 34 IS - 3 suppl AU - KAREL SMETANA, JR. AU - JAN BRÁBEK Y1 - 2020/06/01 UR - http://iv.iiarjournals.org/content/34/3_suppl/1589.abstract N2 - COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy. ER -