RT Journal Article
SR Electronic
T1 Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1589
OP 1592
DO 10.21873/invivo.11947
VO 34
IS 3 suppl
A1 KAREL SMETANA, JR.
A1 JAN BRÁBEK
YR 2020
UL http://iv.iiarjournals.org/content/34/3_suppl/1589.abstract
AB COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy.