@article {CUCCIA1283, author = {FRANCESCO CUCCIA and GIANLUCA MORTELLARO and LUCIA OGNIBENE and GIUSEPPE CRAPARO and ANTONIO LO CASTO and GIUSEPPE FERRERA}, title = {Salvage Re-irradiation Options in Adult Medulloblastoma: A Case Report and Review of the Literature}, volume = {34}, number = {3}, pages = {1283--1288}, year = {2020}, doi = {10.21873/invivo.11903}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage re-irradiation collecting very heterogeneous series. Case Report: A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Conclusion: Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/34/3/1283}, eprint = {https://iv.iiarjournals.org/content/34/3/1283.full.pdf}, journal = {In Vivo} }