TY - JOUR T1 - Cervical Pathology Following HPV Vaccination in Greece: A 10-year HeCPA Observational Cohort Study JF - In Vivo JO - In Vivo SP - 1445 LP - 1449 DO - 10.21873/invivo.11927 VL - 34 IS - 3 AU - EVANGELOS PARASKEVAIDIS AU - ANTONIOS ATHANASIOU AU - MARIA PARASKEVAIDI AU - EVRIPIDIS BILIRAKIS AU - GEORGIOS GALAZIOS AU - EMMANUEL KONTOMANOLIS AU - KONSTANTINOS DINAS AU - ARISTOTELIS LOUFOPOULOS AU - MARIA NASIOUTZIKI AU - IOANNIS KALOGIANNIDIS AU - APOSTOLOS ATHANASIADIS AU - ALEXIOS PAPANIKOLAOU AU - ANASTASIA VATOPOULOU AU - GREGORIOS GRIMBIZIS AU - DIMITRIOS TSOLAKIDIS AU - ALEXANDROS DAPONTE AU - GEORGE VALASOULIS AU - STELLA GRITZELI AU - GEORGIOS MICHAIL AU - GEORGIOS ADONAKIS AU - MINAS PASCHOPOULOS AU - ORESTIS TSONIS AU - MARIA-EUGENIA ANAFORIDOU AU - ANNA BATISTATOU AU - MARIA KYRGIOU AU - the HeCPA (Hellenic Cervical Pathology Academic) Group Y1 - 2020/05/01 UR - http://iv.iiarjournals.org/content/34/3/1445.abstract N2 - Background: In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy. Patients and Methods: This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for colposcopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected. Results: A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated. Conclusion: HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity. ER -