PT - JOURNAL ARTICLE AU - KENICHIRO TORITANI AU - HIDEAKI KIMURA AU - REIKO KUNISAKI AU - JUN WATANABE AU - CHIKARA KUNISAKI AU - ATSUSHI ISHIBE AU - SAWAKO CHIBA AU - YOSHIAKI INAYAMA AU - ITARU ENDO TI - Uselessness of Serum p53 Antibody for Detecting Colitis-associated Cancer in the Era of Immunosuppressive Therapy AID - 10.21873/invivo.11830 DP - 2020 Mar 01 TA - In Vivo PG - 723--728 VI - 34 IP - 2 4099 - http://iv.iiarjournals.org/content/34/2/723.short 4100 - http://iv.iiarjournals.org/content/34/2/723.full SO - In Vivo2020 Mar 01; 34 AB - Background/Aim: The present study examined the utility of serum p53 antibody (Ab) for detecting colitis-associated cancer (CAC) in the era of immunosuppressive therapy. Patients and Methods: Two hundred and fifty patients were analyzed, 219 had no carcinoma or dysplasia (Group non-CAC), and 31 had carcinoma or dysplasia (Group CAC). Serum p53 Abs were detected with an enzyme-linked immunosorbent assay. Immunohistochemical detection was performed in Group CAC. Results: Immunosuppressive therapy was performed in 98.1% of Group non-CAC and 80.6% of Group CAC. There were no differences in serum p53 Abs positivity between Groups non-CAC and CAC (8.7% vs. 3.2%, p=0.30). p53 staining positivity was noted in 90.3% of Group CAC, and the rate of serum p53 positivity was significantly lower in patients with immunosuppressive therapy than in those without in Group CAC (0.0% vs. 16.7%, p=0.04). Conclusion: The utility of serum p53 Ab for detecting CAC is dubious in the era of immunosuppressive therapy.