TY - JOUR T1 - Elderly Patients With Single Brain Metastasis – Overall Survival After Surgery Plus Whole-Brain Irradiation and a Radiation Boost JF - In Vivo JO - In Vivo SP - 1421 LP - 1425 DO - 10.21873/invivo.11923 VL - 34 IS - 3 AU - DIRK RADES AU - TRANG NGUYEN AU - STEVEN E. SCHILD Y1 - 2020/05/01 UR - http://iv.iiarjournals.org/content/34/3/1421.abstract N2 - Background/Aim: Elderly patients with a single brain metastasis likely benefit from personalized treatment protocols. To add to treatment personalization, a survival score was generated for these patients. Patients and Methods: This retrospective study included 36 elderly patients, each with a single brain metastasis, who received surgery followed by whole-brain irradiation and a radiation boost. Six pre-treatment characteristics were evaluated regarding survival, namely age, gender, Karnofsky performance score (KPS), type of primary tumor, non-cerebral metastasis and interval from diagnosis of the neoplasm until surgery. Results: When applying the Cox regression model, KPS (p=0.005) and tumor type (p=0.018) were significant and incorporated in the score. Based on 12-month survival probabilities, three groups of 6-9 (n=5), 10-11 (n=15) and 14-19 points (n=16) were formed, with 12-month survival rates of 0%, 33% and 100%, respectively (p<0.0001). Conclusion: A survival score was generated specifically for elderly patients with a single brain metastasis that can improve personalization of their treatment. ER -