PT  - JOURNAL ARTICLE
AU  - DIRK RADES
AU  - TRANG NGUYEN
AU  - STEVEN E. SCHILD
TI  - Elderly Patients With Single Brain Metastasis – Overall Survival After Surgery Plus Whole-Brain Irradiation and a Radiation Boost
AID  - 10.21873/invivo.11923
DP  - 2020 May 01
TA  - In Vivo
PG  - 1421--1425
VI  - 34
IP  - 3
4099  - http://iv.iiarjournals.org/content/34/3/1421.short
4100  - http://iv.iiarjournals.org/content/34/3/1421.full
SO  - In Vivo2020 May 01; 34
AB  - Background/Aim: Elderly patients with a single brain metastasis likely benefit from personalized treatment protocols. To add to treatment personalization, a survival score was generated for these patients. Patients and Methods: This retrospective study included 36 elderly patients, each with a single brain metastasis, who received surgery followed by whole-brain irradiation and a radiation boost. Six pre-treatment characteristics were evaluated regarding survival, namely age, gender, Karnofsky performance score (KPS), type of primary tumor, non-cerebral metastasis and interval from diagnosis of the neoplasm until surgery. Results: When applying the Cox regression model, KPS (p=0.005) and tumor type (p=0.018) were significant and incorporated in the score. Based on 12-month survival probabilities, three groups of 6-9 (n=5), 10-11 (n=15) and 14-19 points (n=16) were formed, with 12-month survival rates of 0%, 33% and 100%, respectively (p<0.0001). Conclusion: A survival score was generated specifically for elderly patients with a single brain metastasis that can improve personalization of their treatment.