RT Journal Article
SR Electronic
T1 Efficiency of Gastrointestinal Cancer Detection by Nematode-NOSE (N-NOSE)
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 73
OP 80
DO 10.21873/invivo.11747
VO 34
IS 1
A1 HIROTAKE KUSUMOTO
A1 KOTARO TASHIRO
A1 SYUNJI SHIMAOKA
A1 KOICHIRO TSUKASA
A1 YUKIKO BABA
A1 SAORI FURUKAWA
A1 JUNICHIRO FURUKAWA
A1 TORU NIIHARA
A1 TAKAAKI HIROTSU
A1 TAKAYUKI UOZUMI
YR 2020
UL http://iv.iiarjournals.org/content/34/1/73.abstract
AB Background/Aim: Early detection of gastrointestinal cancer may reduce mortality. Recently, Caenorhabditis elegans has been reported to be capable of differentiating patients with cancers from healthy persons by the smell of urine. This novel technique using C. elegans olfaction has been named as Nematode-NOSE (N-NOSE). Materials and Methods: We collected 180 urine samples from patients with gastrointestinal cancer and 76 samples from healthy subjects. N-NOSE test was performed using these samples and N-NOSE index was obtained. Quantification of the olfactory behavior of C. elegans was performed as established in past studies. By receiver operating characteristic (ROC) analysis, we examined the diagnostic capability of N-NOSE. Results: ROC analysis revealed that N-NOSE showed an area under the curve value of more than 0.80, even in early-stage cancers. Conclusion: C. elegans olfaction enabled the detection of gastrointestinal cancers from urine with high sensitivity, which can provide the basis for the development of N-NOSE as a gastrointestinal cancer screening test.