PT  - JOURNAL ARTICLE
AU  - GAZANFER BELGE
AU  - FRANCESCA GROBELNY
AU  - CORD MATTHIES
AU  - ARLO RADTKE
AU  - KLAUS-PETER DIECKMANN
TI  - Serum Level of microRNA-375-3p Is Not a Reliable Biomarker of Teratoma
AID  - 10.21873/invivo.11757
DP  - 2020 Jan 01
TA  - In Vivo
PG  - 163--168
VI  - 34
IP  - 1
4099  - http://iv.iiarjournals.org/content/34/1/163.short
4100  - http://iv.iiarjournals.org/content/34/1/163.full
SO  - In Vivo2020 Jan 01; 34
AB  - Background/Aim: Clinical management of testicular germ cell tumours (GCT) is based upon the measurement of serum tumour markers. Recent studies have shown that the microRNA-371a-3p is a sensitive and specific serum biomarker for all subgroups of GCT, except teratoma. To close the diagnostic gap relating to teratoma, serum levels of microRNA-375-3p have recently been suggested to represent a specific serum marker of this histological subgroup. In the present study, we tested this hypothesis. Materials and Methods: miRNA expression was analysed in serum of 21 GCT patients with teratoma, twelve patients with other GCT, and twelve male controls using the qPCR method. Results: The serum miR-375-3p levels of teratoma patients were not different from other GCT patients or controls. The ROC analysis revealed an AUC of 0.524 for the discrimination between teratoma and other pathologies. Conclusion: The miR-375-3p does probably not qualify for a useful serum biomarker to distinguish teratoma from other GCTs and from controls.