RT Journal Article
SR Electronic
T1 Clinical Implication of Pre-operative C-reactive Protein-Albumin Ratio as a Prognostic Factor of Patients With Pancreatic Ductal Adenocarcinoma: A Single-institutional Retrospective Study
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 347
OP 353
DO 10.21873/invivo.11780
VO 34
IS 1
A1 MURAKAWA, MASAAKI
A1 YAMAMOTO, NAOTO
A1 KAMIOKA, YUTO
A1 KAMIYA, MARIKO
A1 KOBAYASHI, SATOSHI
A1 UENO, MAKOTO
A1 MORIMOTO, MANABU
A1 ATSUMI, YOSUKE
A1 AOYAMA, TORU
A1 TAMAGAWA, HIROSHI
A1 YUKAWA, NORIO
A1 RINO, YASUSHI
A1 MASUDA, MUNETAKA
A1 MORINAGA, SOICHIRO
YR 2020
UL http://iv.iiarjournals.org/content/34/1/347.abstract
AB Background: The C-reactive protein (CRP)-to-serum albumin ratio is associated with a poor prognosis in patients with several cancers. The purpose of this study was to clarify the relationship between the preoperative CRP/Alb ratio and overall survival of pancreatic ductal adenocarcinoma (PDAC) in patients who received radical surgery and S-1 adjuvant chemotherapy. Patients and Methods: We included 117 patients who underwent radical surgery with S-1 adjuvant chemotherapy. We constructed receiver operating characteristic curve (ROC curve) of the CRP/Alb ratio to determine the cut-off value. We analyzed the relationship among the CRP/Alb ratio, clinicopathological status, and survival. Results: The optimal cut-off value of the CRP/Alb ratio was 0.036. All patients were divided into a high-ratio group (CRP/Alb ratio ≥0.036) and low-ratio group (CRP/Alb ratio <0.036). The 5-year overall survival (OS) rates in the high- and low-ratio groups were 22.5% and 36.4%, respectively (p=0.0089). The 5-year disease-free survival (DFS) rates in the high- and low-ratio groups were 12.5% and 22.1%, respectively (p=0.0097). The univariate and multivariate analyses of the OS showed that the pathological N factor and CRP/Alb ratio were independent factors of the survival. The univariate and multivariate analyses of the RFS showed that the pathological N factor, resection margin, and CRP/Alb ratio were independent factors of the survival. Conclusion: The preoperative CRP/Alb ratio is a strong prognostic factor for PDAC patients with undergo curative resection with S-1 adjuvant chemotherapy.