<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MURAKAWA, MASAAKI</style></author><author><style face="normal" font="default" size="100%">YAMAMOTO, NAOTO</style></author><author><style face="normal" font="default" size="100%">KAMIOKA, YUTO</style></author><author><style face="normal" font="default" size="100%">KAMIYA, MARIKO</style></author><author><style face="normal" font="default" size="100%">KOBAYASHI, SATOSHI</style></author><author><style face="normal" font="default" size="100%">UENO, MAKOTO</style></author><author><style face="normal" font="default" size="100%">MORIMOTO, MANABU</style></author><author><style face="normal" font="default" size="100%">ATSUMI, YOSUKE</style></author><author><style face="normal" font="default" size="100%">AOYAMA, TORU</style></author><author><style face="normal" font="default" size="100%">TAMAGAWA, HIROSHI</style></author><author><style face="normal" font="default" size="100%">YUKAWA, NORIO</style></author><author><style face="normal" font="default" size="100%">RINO, YASUSHI</style></author><author><style face="normal" font="default" size="100%">MASUDA, MUNETAKA</style></author><author><style face="normal" font="default" size="100%">MORINAGA, SOICHIRO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Clinical Implication of Pre-operative C-reactive Protein-Albumin Ratio as a Prognostic Factor of Patients With Pancreatic Ductal Adenocarcinoma: A Single-institutional Retrospective Study</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020-01-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">347-353</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/invivo.11780</style></doi><volume><style face="normal" font="default" size="100%">34</style></volume><issue><style face="normal" font="default" size="100%">1</style></issue><abstract><style  face="normal" font="default" size="100%">Background: The C-reactive protein (CRP)-to-serum albumin ratio is associated with a poor prognosis in patients with several cancers. The purpose of this study was to clarify the relationship between the preoperative CRP/Alb ratio and overall survival of pancreatic ductal adenocarcinoma (PDAC) in patients who received radical surgery and S-1 adjuvant chemotherapy. Patients and Methods: We included 117 patients who underwent radical surgery with S-1 adjuvant chemotherapy. We constructed receiver operating characteristic curve (ROC curve) of the CRP/Alb ratio to determine the cut-off value. We analyzed the relationship among the CRP/Alb ratio, clinicopathological status, and survival. Results: The optimal cut-off value of the CRP/Alb ratio was 0.036. All patients were divided into a high-ratio group (CRP/Alb ratio ≥0.036) and low-ratio group (CRP/Alb ratio &lt;0.036). The 5-year overall survival (OS) rates in the high- and low-ratio groups were 22.5% and 36.4%, respectively (p=0.0089). The 5-year disease-free survival (DFS) rates in the high- and low-ratio groups were 12.5% and 22.1%, respectively (p=0.0097). The univariate and multivariate analyses of the OS showed that the pathological N factor and CRP/Alb ratio were independent factors of the survival. The univariate and multivariate analyses of the RFS showed that the pathological N factor, resection margin, and CRP/Alb ratio were independent factors of the survival. Conclusion: The preoperative CRP/Alb ratio is a strong prognostic factor for PDAC patients with undergo curative resection with S-1 adjuvant chemotherapy.</style></abstract></record></records></xml>