PT  - JOURNAL ARTICLE
AU  - PEI-SHIN HU
AU  - YUN-CHI WANG
AU  - CHENG-HSI LIAO
AU  - NING-YI HSIA
AU  - MENG-FENG WU
AU  - JAI-SING YANG
AU  - CHIEN-CHIH YU
AU  - WEN-SHIN CHANG
AU  - DA-TIAN BAU
AU  - CHIA-WEN TSAI
TI  - The Association of <em>MMP7</em> Genotype With Pterygium
AID  - 10.21873/invivo.11744
DP  - 2020 Jan 01
TA  - In Vivo
PG  - 51--56
VI  - 34
IP  - 1
4099  - http://iv.iiarjournals.org/content/34/1/51.short
4100  - http://iv.iiarjournals.org/content/34/1/51.full
SO  - In Vivo2020 Jan 01; 34
AB  - Background/Aim: In literature, few studies have examined the diagnostic or prognostic potential of matrix metalloproteinases (MMP) in pterygium, whose formation and progression are closely related to imbalance in the extracellular microenvironment. In this study, we investigated the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to pterygium risk. Materials and Methods: A total of 134 cases and 268 controls were collected and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The AA, AG and GG genotypes at MMP7 promoter A-181G were non-significantly differentially distributed between the two groups at 85.8, 11.2 and 3.0%, respectively, in pterygium cases and 88.4, 9.7 and 1.9% in controls, respectively (p for trend=0.6822). There was no polymorphic genotype for MMP7 C-153T among our Taiwanese cohort. Conclusion: A-181G and C-153T genotypes at MMP7 do not have a direct role in determining Taiwanese susceptibility to pterygium.