RT Journal Article
SR Electronic
T1 Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1737
OP 1749
DO 10.21873/invivo.11664
VO 33
IS 6
A1 SIMOPOULOU, MARA
A1 SFAKIANOUDIS, KONSTANTINOS
A1 MAZIOTIS, EVANGELOS
A1 TSIOULOU, PETROULA
A1 GIANNELOU, POLINA
A1 GRIGORIADIS, SOKRATIS
A1 PANTOU, AGNI
A1 ANIFANDIS, GEORGE
A1 CHRISTOPOULOS, PANAGIOTIS
A1 PANTOS, KONSTANTINOS
A1 KOUTSILIERIS, MICHAEL
YR 2019
UL http://iv.iiarjournals.org/content/33/6/1737.abstract
AB Background/Aim: Studies on the impact of intrauterine human Chorionic Gonadotropin (hCG) administration in order to improve the In Vitro Fertilization (IVF) outcome have yielded conflicting results. The aim of the present systematic review and meta-analysis is to investigate whether timing of intrauterine hCG administration prior to embryo transfer affects its efficiency. Materials and Methods: A systematic search of the literature on Pubmed/Medline, Embase and Cochrane databases was performed. Only Randomized Control Trials were included in this meta-analysis. Results: Live birth rates were not improved following hCG administration (RR=1.13, 95%CI=0.88-1.46, p=0.34) in the pooled results. Combined live birth and ongoing pregnancy rates were borderline statistically significant following hCG administration (RR=1.27, 95%CI=1.00-1.62, p=0.05). Following subgroup analysis regarding live birth and ongoing pregnancy rates, only the 5-12 minutes prior to the embryo transfer group reported a statistically significant improvement. Conclusion: Intrauterine infusion of hCG within an IVF-Intracytoplasmic Sperm Injection (ICSI) cycle improves outcome only when administered 5-12 min prior to embryo transfer.