PT  - JOURNAL ARTICLE
AU  - HIROKAZU TOSHIMA
AU  - TOSHIKAZU IKUSUE
AU  - ATSUSHI HISAMATSU
AU  - KOUJI KOBAYASHI
AU  - HIROO ISHIDA
AU  - KEN SHIMADA
TI  - VEGF Inhibitors Do Not Increase D-dimer Levels in Colorectal Cancer Patients Without Venous Thromboembolism : A Retrospective Non-inferiority Analysis
AID  - 10.21873/invivo.11712
DP  - 2019 Nov 01
TA  - In Vivo
PG  - 2117--2123
VI  - 33
IP  - 6
4099  - http://iv.iiarjournals.org/content/33/6/2117.short
4100  - http://iv.iiarjournals.org/content/33/6/2117.full
SO  - In Vivo2019 Nov 01; 33
AB  - Background/Aim: If VEGF inhibitors contribute to an increase in D-dimer levels, they may adversely affect the diagnosis of venous thromboembolism (VTE). Consequently, this retrospective study examined the effects of VEGF inhibitors on D-dimer levels in colorectal cancer patients. Patients and Methods: A total of 104 colorectal cancer patients who received chemotherapy, were included in this study. To perform D-dimer analysis, patients were divided into two analysis targets: patients with VTE and without VTE. Statistical analysis included a natural logarithmic transformation of D-dimer data. Results: In the D-dimer analysis of non-VTE patients, the natural logarithm D-dimer mean difference was −0.186, with a 95% CI of −0.525 to 0.154. The upper limit of the 95%CI (0.154) did not exceed the non-inferiority margin (Δ) of 0.199, and therefore met the non-inferiority criteria. Conclusion: VEGF inhibitors don't contribute to increased D-dimer levels in colorectal cancer patients without VTE.