%0 Journal Article %A HIROKAZU TOSHIMA %A TOSHIKAZU IKUSUE %A ATSUSHI HISAMATSU %A KOUJI KOBAYASHI %A HIROO ISHIDA %A KEN SHIMADA %T VEGF Inhibitors Do Not Increase D-dimer Levels in Colorectal Cancer Patients Without Venous Thromboembolism : A Retrospective Non-inferiority Analysis %D 2019 %R 10.21873/invivo.11712 %J In Vivo %P 2117-2123 %V 33 %N 6 %X Background/Aim: If VEGF inhibitors contribute to an increase in D-dimer levels, they may adversely affect the diagnosis of venous thromboembolism (VTE). Consequently, this retrospective study examined the effects of VEGF inhibitors on D-dimer levels in colorectal cancer patients. Patients and Methods: A total of 104 colorectal cancer patients who received chemotherapy, were included in this study. To perform D-dimer analysis, patients were divided into two analysis targets: patients with VTE and without VTE. Statistical analysis included a natural logarithmic transformation of D-dimer data. Results: In the D-dimer analysis of non-VTE patients, the natural logarithm D-dimer mean difference was −0.186, with a 95% CI of −0.525 to 0.154. The upper limit of the 95%CI (0.154) did not exceed the non-inferiority margin (Δ) of 0.199, and therefore met the non-inferiority criteria. Conclusion: VEGF inhibitors don't contribute to increased D-dimer levels in colorectal cancer patients without VTE. %U https://iv.iiarjournals.org/content/invivo/33/6/2117.full.pdf