PT - JOURNAL ARTICLE AU - KIL JUN JEONG AU - EUISIN YANG AU - KWANGSIK JANG AU - KYUNG MI SHIM AU - CHUN-SIK BAE AU - SE EUN KIM AU - SEONG SOO KANG TI - Successful Clinical Application of Cancellous Allografts With Structural Support for Failed Bone Fracture Healing in Dogs AID - 10.21873/invivo.11673 DP - 2019 Nov 01 TA - In Vivo PG - 1813--1818 VI - 33 IP - 6 4099 - http://iv.iiarjournals.org/content/33/6/1813.short 4100 - http://iv.iiarjournals.org/content/33/6/1813.full SO - In Vivo2019 Nov 01; 33 AB - Background/Aim: In Korea, small breed dogs including Maltese, Pomeranians, and Yorkshire Terriers are most common. These small dogs are at increased risk for the development of delayed union or nonunion fractures, particularly when the fracture occurs at a site with insufficient surrounded soft tissue such as the ulna and radius. To treat failed bone fracture healing, stable fixation of the fracture and implantation of bone grafts are needed. Among the various types of bone grafts, autograft is considered to be the gold standard. However, the amount of autograft available for harvesting in small dogs is limited. In this study, we report on a novel canine cancellous allograft (C350C) that was prepared using chemicals and low heat treatment (350°C). Patients and Methods: We applied C350C in two cases with failed bone fracture healing. Due to the poor osteoinductive capabilities of C350C, we also used recombinant human bone morphogenetic protein-2 (rhBMP-2) and Matrigel as osteoinductive and delivery agents, respectively. Results: In both cases, the fractures healed successfully. Conclusion: C350C can be used as a bone graft material that could replace autografts in cases with failed bone fracture healing.