TY - JOUR T1 - Impact of Awake Breast Cancer Surgery on Postoperative Lymphocyte Responses JF - In Vivo JO - In Vivo SP - 1879 LP - 1884 DO - 10.21873/invivo.11681 VL - 33 IS - 6 AU - GIANLUCA VANNI AU - MARCO MATERAZZO AU - TOMMASO PERRETTA AU - ROSARIA MEUCCI AU - LUCIA ANEMONA AU - CHIARA BUONOMO AU - MARIO DAURI AU - ALESSANDRA VITTORIA GRANAI AU - MAURIZIO RHO AU - SARA INGALLINELLA AU - FEDERICO TACCONI AU - VINCENZO AMBROGI AU - AGOSTINO CHIARAVALLOTI AU - ORAZIO SCHILLACI AU - GIUSEPPE PETRELLA AU - ORESTE CLAUDIO BUONOMO Y1 - 2019/11/01 UR - http://iv.iiarjournals.org/content/33/6/1879.abstract N2 - Background: Surgical stress and anesthesia affect the patient's immune system. Analysis of the lymphocyte response after breast-conserving surgery was conducted to investigate the differences between effects after general and local anesthesia. Materials and Methods: Fifty-six patients with breast cancer were enrolled for BCS through local or general anesthesia. Total leukocytes, total lymphocytes, lymphocyte-subsets including CD3+, CD19+, CD4+, CD8+, CD16+CD56+ and CD4+/CD8+ ratio was examined at baseline and on postoperative days 1, 2 and 3. Results: Baseline data showed no statistical difference between the two groups. Within-group ANOVA test showed significant differences for total leukocyte count (p<0.001), total lymphocyte count (p=0.009) and proportion of natural-killer cells (p=0.01) in the control group. Between-group analysis showed lower median values of total lymphocytes in the awake surgery group on postoperative days 1, 2 and 3 (p=0.001, p=0.02 and p=0.01, respectively) when compared to the control group. Patients who underwent surgery under general anesthesia had higher total lymphocyte counts on postoperative day 2 (p=0.04). Conclusion: In this randomized study, breast-conserving surgery plus local anesthesia had a lower impact on postoperative lymphocyte response when compared to the same procedure performed under general anesthesia. ER -