RT Journal Article
SR Electronic
T1 C-Reactive Protein Gene Variants and Their Serum Levels in Early Adult-onset Type 2 Diabetes Mellitus
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1685
OP 1690
DO 10.21873/invivo.11656
VO 33
IS 5
A1 HUANG, YU-CHUEN
A1 CHEN, CHING-CHU
A1 WANG, TZU-YUAN
A1 NGUYEN, HUNG TRAN THE
A1 CHEN, YUNG-HSIANG
A1 WU, CHIA-MING
A1 CHANG, YA-WEN
A1 LIAO, WEN-LING
A1 TSAI, FUU-JEN
YR 2019
UL http://iv.iiarjournals.org/content/33/5/1685.abstract
AB Background/Aim: C-Reactive protein (CRP) is a common marker of inflammation. Elevated CRP levels have been associated with increased risk of development of type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association of CRP gene polymorphisms with early-onset T2DM and the effect of genetic variants on CRP level. Materials and Methods: In total, 948 individuals with early-onset (n=271) or late-onset (n=677) T2DM were enrolled in the study. Five single-nucleotide polymorphisms (SNPs) in the CRP gene, namely rs3093077, rs2808630, rs1800947, rs11265263, and rs11265265, were selected for genotyping, and CRP levels were measured. Results: Genotypic, allelic, and haplotype frequencies of these five SNPs were not significantly different between patients with early- and those with late-onset. T2DM Higher serum CRP levels were independently associated with the C-allele of rs3093077 and T-allele of rs11265265 (p<0.001). Furthermore, the C-allele of rs3093077 was associated with higher CRP level in both early- (p=0.016) and late-onset (p<0.001) T2DM. Conclusion: CRP gene variants may contribute to the risk of early-onset T2DM by affecting the serum CRP level.