RT Journal Article SR Electronic T1 Circulating Tumor Cell Counts in Patients With Localized Prostate Cancer Including Those Under Active Surveillance JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 1615 OP 1620 DO 10.21873/invivo.11645 VO 33 IS 5 A1 SE YOUNG CHOI A1 BUMJIN LIM A1 YOON SOO KYUNG A1 YUNLIM KIM A1 BONG MIN KIM A1 BYUNG HEE JEON A1 JAE CHAN PARK A1 YOUNG WOONG SOHN A1 JAE HYUK LEE A1 JI-HYUN UH A1 SEONGSOO JANG A1 CHOUNG-SOO KIM YR 2019 UL http://iv.iiarjournals.org/content/33/5/1615.abstract AB Aim: To evaluate the clinical efficacy of a circulating tumor cell (CTC) test by comparison between healthy volunteers and patients with localized prostate cancer including those under active surveillance. Materials and Methods: CTC counts in peripheral blood were compared between patients with prostate cancer (n=45) and healthy volunteers (n=17). CTCs were identified based on the expression of epithelial cell adhesion molecule (EpCAM) and counted using a SMART BIOPSY™ SYSTEM. Results: The number of EpCAM+ cells was significantly higher in patients with cancer than in healthy volunteers. Among the low-risk patients (n=9), two had up-staging and six had up-grading. Among those up-staged, there was one case which was EpCAM+. Among those cases up-graded, three were EpCAM+. In those with stage T2 tumors, the presence of Gleason pattern 5 was positively correlated with EpCAM positivity (rho=0.59, p<0.001). Conclusion: CTC counts in localized prostate cancer were associated with Gleason pattern 5. Active treatment should be considered for patients with low-risk disease during active surveillance who are found to have EpCAM+ CTCs because of a risk of up-staging and up-grading.