TY - JOUR T1 - Correlation of Cerebroplacental Ratio (CPR) With Adverse Perinatal Outcome in Singleton Pregnancies JF - In Vivo JO - In Vivo SP - 1703 LP - 1706 DO - 10.21873/invivo.11659 VL - 33 IS - 5 AU - BERTHOLD GRÜTTNER AU - JESSIKA RATIU AU - DOMINIK RATIU AU - INGO GOTTSCHALK AU - BERND MORGENSTERN AU - JUDITH SARAH ABEL AU - CHRISTIAN EICHLER AU - CAROLINE PAHMEYER AU - SEBASTIAN LUDWIG AU - PETER MALLMANN AU - FABINSHY THANGARAJAH Y1 - 2019/09/01 UR - http://iv.iiarjournals.org/content/33/5/1703.abstract N2 - Background/Aim: For many years clinical research has been concerned with doppler sonography as a non-invasive tool for intrauterine fetal status assessment. A new focus is now placed on the measurement of cerebroplacental index (CPR) as a predictor of fetal outcome. Our aim was to investigate the relationship between the cerebroplacental ratio (CPR), the delivery mode and the fetal outcome in singleton pregnancies. Patients and Methods: A retrospective cohort study of pregnancies in which doppler sonography of middle cerebral artery (MCA) and umbilical artery (UA) was conducted up to 9 weeks before delivery took place. Patients with pathological (CPR≤1.0) and normal CPR (>1.0) were compared by umbilical cord pH, APGAR scores, birth weight, delivery week and delivery mode. Results: A total of 2,270 singleton pregnancies were included. The APGAR score for 1, 5 and 10 minutes and the gestational age at delivery were significantly lower in the group of patients with pathological CPR (p<0.001). Overall, 50% of the cohort had a cesarean section, the difference between the groups was statistically significant (p<0.001), with a higher amount of cesareans in the group of patients with pathological CPR. The multiple regression analysis showed a significantly improved pH of delivery when cesarean section (p<0.001), female sex of fetus (p=0.013) and higher CPR (p=0.035) were present. Conclusion: The measurement of CPR is an important, non-invasive predictive parameter and leads to the identification of a risk collective even in the non-selected patient population and thus probably to a reduction of perinatal morbidity. ER -