TY - JOUR T1 - Evaluation of Biocompatibility of Different Membrane Surfaces Using Unrestricted Somatic Stem Cells JF - In Vivo JO - In Vivo SP - 1447 LP - 1454 DO - 10.21873/invivo.11623 VL - 33 IS - 5 AU - LARA SCHORN AU - JÖRG HANDSCHEL AU - JULIAN LOMMEN AU - FELIX PAULSSEN VON BECK AU - RITA DEPPRICH AU - NORBERT KÜBLER AU - HENRIK HOLTMANN Y1 - 2019/09/01 UR - http://iv.iiarjournals.org/content/33/5/1447.abstract N2 - Background/Aim: Results of Guided Bone Regeneration (GBR) primarily depend on the membrane used. The aim of this study was to compare biocompatibility of different absorbable and non-absorbable membranes by using unrestricted somatic stem cells (USSCs) as an indicator for biocompatibility. Materials and Methods: Five absorbable membranes (Bio-Gide®, RESODONT®, GENTA-FOIL resorb®, BioMend® and BioMend® Extend™) and one non-absorbable alternative (GORE-TEX®) were colonized with USSCs. After 24 h, 3 days and 7 days, cell proliferation, cell viability, and cytotoxicity were assessed. Moreover, cell morphology was evaluated by electron microscopy. Results: Significantly higher cell proliferation and cell viability rates were observed in Bio-Gide® and RESODONT® membranes. Cell toxicity was highest on GENTA-FOIL resorb® membranes. The electron microscopical assessment showed a better cell attachment on porous surfaced membranes. Conclusion: This study shows that USSCs can be used for assessments of biocompatibility, and that absorbable membranes with collagenous composition and porous structure tend to positively impact biocompatibility and enhance cell proliferation. ER -