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Research ArticleClinical Studies
Open Access

HLA Class I Loss and Resistance to Immunotherapy in Pulmonary Metastasis of Hypopharyngeal Cancer

AKIRA MURAKAMI, KAORI YUKINO, YOSHIHIRO KOMOHARA, YU SHIMODA, HARUKI SAITO, YUKIO FUJIWARA and YORIHISA ORITA
In Vivo May 2026, 40 (3) 1753-1759; DOI: https://doi.org/10.21873/invivo.14327
AKIRA MURAKAMI
1Departments of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;
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KAORI YUKINO
1Departments of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;
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YOSHIHIRO KOMOHARA
2Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
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  • For correspondence: ycomo{at}kumamoto-u.ac.jp
YU SHIMODA
1Departments of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;
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HARUKI SAITO
1Departments of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;
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YUKIO FUJIWARA
2Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
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YORIHISA ORITA
1Departments of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;
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Article Information

vol. 40 no. 3 1753-1759
DOI 
https://doi.org/10.21873/invivo.14327
PMID 
42049418

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received January 7, 2026
  • Revision received February 8, 2026
  • Accepted February 11, 2026
  • Published online April 28, 2026.

Copyright & License 
Copyright © 2026 The Author(s). Published by the International Institute of Anticancer Research. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Author Information

  1. AKIRA MURAKAMI1,
  2. KAORI YUKINO1,
  3. YOSHIHIRO KOMOHARA2⇑,
  4. YU SHIMODA1,
  5. HARUKI SAITO1,
  6. YUKIO FUJIWARA2 and
  7. YORIHISA ORITA1
  1. 1Departments of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;
  2. 2Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
  1. Yoshihiro Komohara, Department of Cell Pathology, Graduate School of Medicine, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. Tel: +81 963735095, Fax: +81 963735096, e-mail: ycomo{at}kumamoto-u.ac.jp
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In Vivo: 40 (3)
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HLA Class I Loss and Resistance to Immunotherapy in Pulmonary Metastasis of Hypopharyngeal Cancer
AKIRA MURAKAMI, KAORI YUKINO, YOSHIHIRO KOMOHARA, YU SHIMODA, HARUKI SAITO, YUKIO FUJIWARA, YORIHISA ORITA
In Vivo May 2026, 40 (3) 1753-1759; DOI: 10.21873/invivo.14327

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HLA Class I Loss and Resistance to Immunotherapy in Pulmonary Metastasis of Hypopharyngeal Cancer
AKIRA MURAKAMI, KAORI YUKINO, YOSHIHIRO KOMOHARA, YU SHIMODA, HARUKI SAITO, YUKIO FUJIWARA, YORIHISA ORITA
In Vivo May 2026, 40 (3) 1753-1759; DOI: 10.21873/invivo.14327
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Keywords

  • immune checkpoint inhibitor
  • head and neck squamous cell carcinoma (HNSCC)
  • pulmonary metastasis
  • β2-microglobulin
  • immune escape
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