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Research ArticleClinical Studies
Open Access

Comparison of Early Response to Selumetinib Therapy in Adolescents and Children With NF1-related Plexiform Neurofibromas

JAGODA STYCZYŃSKA, AGATA MARJAŃSKA, AGNIESZKA JATCZAK-GACA, MAREK KARWACKI, JUSTYNA WALENCIAK, KATARZYNA GARUS, KATARZYNA BILSKA, AGNIESZKA MIZIA-MALARZ, WANDA BADOWSKA, DOROTA SŁAWIŃSKA, JADWIGA WĘCŁAWEK-TOMPOL, RADOSŁAW CHABER, EWA BIEŃ, MICHALINA JEZIERSKA, GRAŻYNA KAROLCZYK, JOLANTA SKALSKA-SADOWSKA and JAN STYCZYŃSKI
In Vivo May 2026, 40 (3) 1621-1627; DOI: https://doi.org/10.21873/invivo.14312
JAGODA STYCZYŃSKA
1Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Collegium Medicum, Nicolaus Copernicus University Torun, Jurasz University Hospital, Bydgoszcz, Poland;
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  • For correspondence: jagasadlok{at}gmail.com
AGATA MARJAŃSKA
1Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Collegium Medicum, Nicolaus Copernicus University Torun, Jurasz University Hospital, Bydgoszcz, Poland;
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AGNIESZKA JATCZAK-GACA
1Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Collegium Medicum, Nicolaus Copernicus University Torun, Jurasz University Hospital, Bydgoszcz, Poland;
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MAREK KARWACKI
2Department of Pediatric Hematology and Oncology, Clinical Transplantology and Pediatrics, Medical University of Warsaw, Warsaw, Poland;
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JUSTYNA WALENCIAK
3Department of Pediatrics, Oncology and Hematology, Medical University, Łódź, Poland;
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KATARZYNA GARUS
4Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland;
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KATARZYNA BILSKA
5Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, Warsaw, Poland;
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AGNIESZKA MIZIA-MALARZ
6Department of Oncology, Hematology and Chemotherapy, Division of Pediatrics, Medical University of Silesia, Upper Silesian Child Health Centre, Katowice, Poland;
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WANDA BADOWSKA
7Department of Pediatrics and Hematology and Oncology, Province Children’s Hospital, Olsztyn, Poland;
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DOROTA SŁAWIŃSKA
8Department of Pediatric Haematology and Oncology and Transplantology, Medical University, Lublin, Poland;
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JADWIGA WĘCŁAWEK-TOMPOL
9Department of Pediatric Hematology/Oncology and BMT, Medical University, Wrocław, Poland;
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RADOSŁAW CHABER
10Department of Pediatrics, Institute of Medical Sciences, Collegium Medicum, University of Rzeszów, Rzeszów, Poland;
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EWA BIEŃ
11Department of Pediatrics, Hematology and Oncology, Medical University, Gdańsk, Poland;
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MICHALINA JEZIERSKA
11Department of Pediatrics, Hematology and Oncology, Medical University, Gdańsk, Poland;
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GRAŻYNA KAROLCZYK
12Department of Pediatric Oncology and Hematology, Children’s Hospital in Kielce, Kielce, Poland;
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JOLANTA SKALSKA-SADOWSKA
13Department of Pediatric Oncology, Hematology and Transplantology, Poznań University of Medical Sciences, Poznań, Poland
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JAN STYCZYŃSKI
1Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Collegium Medicum, Nicolaus Copernicus University Torun, Jurasz University Hospital, Bydgoszcz, Poland;
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Article Information

vol. 40 no. 3 1621-1627
DOI 
https://doi.org/10.21873/invivo.14312
PMID 
42049404

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received January 9, 2026
  • Revision received February 9, 2026
  • Accepted February 11, 2026
  • Published online April 28, 2026.

Copyright & License 
Copyright © 2026 The Author(s). Published by the International Institute of Anticancer Research. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Author Information

  1. JAGODA STYCZYŃSKA1⇑,
  2. AGATA MARJAŃSKA1,
  3. AGNIESZKA JATCZAK-GACA1,
  4. MAREK KARWACKI2,
  5. JUSTYNA WALENCIAK3,
  6. KATARZYNA GARUS4,
  7. KATARZYNA BILSKA5,
  8. AGNIESZKA MIZIA-MALARZ6,
  9. WANDA BADOWSKA7,
  10. DOROTA SŁAWIŃSKA8,
  11. JADWIGA WĘCŁAWEK-TOMPOL9,
  12. RADOSŁAW CHABER10,
  13. EWA BIEŃ11,
  14. MICHALINA JEZIERSKA11,
  15. GRAŻYNA KAROLCZYK12,
  16. JOLANTA SKALSKA-SADOWSKA13 and
  17. JAN STYCZYŃSKI1
  1. 1Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Collegium Medicum, Nicolaus Copernicus University Torun, Jurasz University Hospital, Bydgoszcz, Poland;
  2. 2Department of Pediatric Hematology and Oncology, Clinical Transplantology and Pediatrics, Medical University of Warsaw, Warsaw, Poland;
  3. 3Department of Pediatrics, Oncology and Hematology, Medical University, Łódź, Poland;
  4. 4Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland;
  5. 5Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, Warsaw, Poland;
  6. 6Department of Oncology, Hematology and Chemotherapy, Division of Pediatrics, Medical University of Silesia, Upper Silesian Child Health Centre, Katowice, Poland;
  7. 7Department of Pediatrics and Hematology and Oncology, Province Children’s Hospital, Olsztyn, Poland;
  8. 8Department of Pediatric Haematology and Oncology and Transplantology, Medical University, Lublin, Poland;
  9. 9Department of Pediatric Hematology/Oncology and BMT, Medical University, Wrocław, Poland;
  10. 10Department of Pediatrics, Institute of Medical Sciences, Collegium Medicum, University of Rzeszów, Rzeszów, Poland;
  11. 11Department of Pediatrics, Hematology and Oncology, Medical University, Gdańsk, Poland;
  12. 12Department of Pediatric Oncology and Hematology, Children’s Hospital in Kielce, Kielce, Poland;
  13. 13Department of Pediatric Oncology, Hematology and Transplantology, Poznań University of Medical Sciences, Poznań, Poland
  1. Jagoda Styczyńska, Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Collegium Medicum, Nicolaus Copernicus University, Antoni Jurasz University Hospital No. 1, ul. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland. Tel: +48 525854860, e-mail: jagasadlok{at}gmail.com
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Comparison of Early Response to Selumetinib Therapy in Adolescents and Children With NF1-related Plexiform Neurofibromas
JAGODA STYCZYŃSKA, AGATA MARJAŃSKA, AGNIESZKA JATCZAK-GACA, MAREK KARWACKI, JUSTYNA WALENCIAK, KATARZYNA GARUS, KATARZYNA BILSKA, AGNIESZKA MIZIA-MALARZ, WANDA BADOWSKA, DOROTA SŁAWIŃSKA, JADWIGA WĘCŁAWEK-TOMPOL, RADOSŁAW CHABER, EWA BIEŃ, MICHALINA JEZIERSKA, GRAŻYNA KAROLCZYK, JOLANTA SKALSKA-SADOWSKA, JAN STYCZYŃSKI
In Vivo May 2026, 40 (3) 1621-1627; DOI: 10.21873/invivo.14312

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Comparison of Early Response to Selumetinib Therapy in Adolescents and Children With NF1-related Plexiform Neurofibromas
JAGODA STYCZYŃSKA, AGATA MARJAŃSKA, AGNIESZKA JATCZAK-GACA, MAREK KARWACKI, JUSTYNA WALENCIAK, KATARZYNA GARUS, KATARZYNA BILSKA, AGNIESZKA MIZIA-MALARZ, WANDA BADOWSKA, DOROTA SŁAWIŃSKA, JADWIGA WĘCŁAWEK-TOMPOL, RADOSŁAW CHABER, EWA BIEŃ, MICHALINA JEZIERSKA, GRAŻYNA KAROLCZYK, JOLANTA SKALSKA-SADOWSKA, JAN STYCZYŃSKI
In Vivo May 2026, 40 (3) 1621-1627; DOI: 10.21873/invivo.14312
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Keywords

  • Neurofibromatosis type 1
  • plexiform neurofibroma
  • selumetinib
  • adolescents
  • children
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