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Research ArticleClinical Studies
Open Access

Helical Tomotherapy in Local Advanced Breast Cancer Following Mastectomy: Long-term Results and Late Toxicity Analysis

LUIS-PHILIPP RAETHER, MICHAEL SCHEMPP, RUDOLF KLEPPER, HENRIK HAUSWALD, SEBASTIAN HOEFEL, PETER E. HUBER, JUERGEN DEBUS and FELIX ZWICKER
In Vivo May 2026, 40 (3) 1552-1569; DOI: https://doi.org/10.21873/invivo.14305
LUIS-PHILIPP RAETHER
1Heidelberg University School of Medicine, Heidelberg, Germany;
2Clinic and Practice of Radiation Oncology/Practice of Radiology, Konstanz, Germany;
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MICHAEL SCHEMPP
2Clinic and Practice of Radiation Oncology/Practice of Radiology, Konstanz, Germany;
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RUDOLF KLEPPER
2Clinic and Practice of Radiation Oncology/Practice of Radiology, Konstanz, Germany;
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HENRIK HAUSWALD
3RNS Gemeinschaftspraxis, Wiesbaden, Germany;
4Clinical Cooperation Unit Molecular Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;
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SEBASTIAN HOEFEL
2Clinic and Practice of Radiation Oncology/Practice of Radiology, Konstanz, Germany;
5Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany;
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PETER E. HUBER
4Clinical Cooperation Unit Molecular Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;
6Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
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JUERGEN DEBUS
4Clinical Cooperation Unit Molecular Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;
6Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
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FELIX ZWICKER
2Clinic and Practice of Radiation Oncology/Practice of Radiology, Konstanz, Germany;
4Clinical Cooperation Unit Molecular Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;
6Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
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  • For correspondence: f.zwicker{at}dkfz.de
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Article Information

vol. 40 no. 3 1552-1569
DOI 
https://doi.org/10.21873/invivo.14305
PMID 
42049401

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received February 11, 2026
  • Revision received March 12, 2026
  • Accepted March 16, 2026
  • Published online April 28, 2026.

Copyright & License 
Copyright © 2026 The Author(s). Published by the International Institute of Anticancer Research. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Author Information

  1. LUIS-PHILIPP RAETHER1,2,
  2. MICHAEL SCHEMPP2,
  3. RUDOLF KLEPPER2,
  4. HENRIK HAUSWALD3,4,
  5. SEBASTIAN HOEFEL2,5,
  6. PETER E. HUBER4,6,
  7. JUERGEN DEBUS4,6 and
  8. FELIX ZWICKER2,4,6⇑
  1. 1Heidelberg University School of Medicine, Heidelberg, Germany;
  2. 2Clinic and Practice of Radiation Oncology/Practice of Radiology, Konstanz, Germany;
  3. 3RNS Gemeinschaftspraxis, Wiesbaden, Germany;
  4. 4Clinical Cooperation Unit Molecular Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;
  5. 5Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany;
  6. 6Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
  1. Felix Zwicker, MD, German Cancer Research Centre (DKFZ) E055, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Tel: +49 (0)622142 2616, e-mail: f.zwicker{at}dkfz.de
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Helical Tomotherapy in Local Advanced Breast Cancer Following Mastectomy: Long-term Results and Late Toxicity Analysis
LUIS-PHILIPP RAETHER, MICHAEL SCHEMPP, RUDOLF KLEPPER, HENRIK HAUSWALD, SEBASTIAN HOEFEL, PETER E. HUBER, JUERGEN DEBUS, FELIX ZWICKER
In Vivo May 2026, 40 (3) 1552-1569; DOI: 10.21873/invivo.14305

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Helical Tomotherapy in Local Advanced Breast Cancer Following Mastectomy: Long-term Results and Late Toxicity Analysis
LUIS-PHILIPP RAETHER, MICHAEL SCHEMPP, RUDOLF KLEPPER, HENRIK HAUSWALD, SEBASTIAN HOEFEL, PETER E. HUBER, JUERGEN DEBUS, FELIX ZWICKER
In Vivo May 2026, 40 (3) 1552-1569; DOI: 10.21873/invivo.14305
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Keywords

  • breast cancer
  • helical tomotherapy
  • mastectomy
  • adjuvant radiotherapy
  • postmastectomy radiation therapy
  • scar boost radiation
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