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Association of Transforming Growth Factor-β1 and α-Smooth Muscle Actin in Experimental Selective Obstructive Cholestasis

RALUCA CRISTINA AILIOAIE, CATALIN CIUCE, VLAD FAGARASAN, CALIN IONESCU and RADU RAZVAN SCURTU
In Vivo May 2026, 40 (3) 1452-1462; DOI: https://doi.org/10.21873/invivo.14296

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Figures

  • Figure 1.
    Figure 1.

    Aspect of the obstructed liver parenchyma. Kupffer cell hyperplasia (arrows) can be seen, with an otherwise preserved liver architecture, with the portal space (PS) and centrolobular vein (CLV) connected by sinusoid capillaries separated by hepatocyte trabeculae. Hematoxylin and eosin, ×400.

  • Figure 2.
    Figure 2.

    Transforming growth factor-β1 expression in the obstructed liver. (A) Moderately diffuse cytoplasmic positivity from edge sample and (B) cytoplasmic particles, predominantly localized at the biliary pole of the hepatocytes. Immunochemistry, ×1,000.

  • Figure 3.
    Figure 3.

    Expression of α-smooth muscle actin in the obstructed liver parenchyma. The expression is identified in pericentrolobular stellate cells (Ito cells involved in fibrotic processes through collagen synthesis). Immunochemistry, ×1,000.

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Association of Transforming Growth Factor-β1 and α-Smooth Muscle Actin in Experimental Selective Obstructive Cholestasis
RALUCA CRISTINA AILIOAIE, CATALIN CIUCE, VLAD FAGARASAN, CALIN IONESCU, RADU RAZVAN SCURTU
In Vivo May 2026, 40 (3) 1452-1462; DOI: 10.21873/invivo.14296
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