Capillary Hemangioma of the Breast Parenchyma Mimicking New Primary Cancer or Metastasis During Ramucirumab Therapy for Advanced Gastric Cancer

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Figure 1.
Chest computed tomography findings during treatment. (A) Chest computed tomography (CT) performed at the time of disease progression after first-line chemotherapy shows no remarkable findings in the left breast parenchyma. (B) A response evaluation CT after two cycles of second-line chemotherapy (paclitaxel plus ramucirumab) shows an enhanced nodule within the left breast parenchyma. (C) Follow-up CT performed two months after discontinuation of ramucirumab shows that the size of the hypervascular nodule has reduced. (D) Final chest CT obtained two months after (C) shows that the entire left breast could not be fully visualized; however, no hypervascular nodule can be identified in the visible portion.
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Figure 2.
Pathological findings of the capillary hemangioma in the left breast. (A) Low-power view [Hematoxylin and Eosin (H&E) stain, ×200] shows numerous capillary-sized vessels proliferating within a fibrous stroma. (B) High-power view (H&E stain, ×400) demonstrates vascular channels lined by bland, single-layered endothelial cells containing red blood cells. No cytologic atypia, mitosis, necrosis, or infiltrative growth pattern can be observed.