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Research ArticleExperimental Studies
Open Access

Lenvatinib Suppresses Colorectal Cancer Cell Growth, Migration, and Invasion via Dual-pathway Apoptosis and ERK/STAT3/NF-κB Inactivation

CHING-HSUAN WU, FEI-TING HSU, CHUN-HSIEN CHEN, PEI-EN WANG, HUAI-YI HUANG, LING-LING HSIEH and CHENG-HSIEN CHEN
In Vivo January 2026, 40 (1) 264-273; DOI: https://doi.org/10.21873/invivo.14189
CHING-HSUAN WU
1Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.;
2Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C.;
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FEI-TING HSU
3Department of Life Sciences, National Central University, Taoyuan, Taiwan, R.O.C.;
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CHUN-HSIEN CHEN
3Department of Life Sciences, National Central University, Taoyuan, Taiwan, R.O.C.;
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PEI-EN WANG
3Department of Life Sciences, National Central University, Taoyuan, Taiwan, R.O.C.;
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HUAI-YI HUANG
4Division of Gastroenterology and Hepatology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.;
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LING-LING HSIEH
2Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C.;
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  • For correspondence: llhsieh2013{at}gmail.com
CHENG-HSIEN CHEN
5Surgical Intensive Care Unit, Department of Surgery, Changhua Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
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  • For correspondence: picorna{at}gmail.com
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Article Information

vol. 40 no. 1 264-273
DOI 
https://doi.org/10.21873/invivo.14189
PMID 
41482360

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received September 26, 2025
  • Revision received October 28, 2025
  • Accepted November 4, 2025
  • Published online January 2, 2026.

Copyright & License 
Copyright © 2026 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. CHING-HSUAN WU1,2,
  2. FEI-TING HSU3,
  3. CHUN-HSIEN CHEN3,
  4. PEI-EN WANG3,
  5. HUAI-YI HUANG4,
  6. LING-LING HSIEH2⇑ and
  7. CHENG-HSIEN CHEN5⇑
  1. 1Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.;
  2. 2Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C.;
  3. 3Department of Life Sciences, National Central University, Taoyuan, Taiwan, R.O.C.;
  4. 4Division of Gastroenterology and Hepatology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.;
  5. 5Surgical Intensive Care Unit, Department of Surgery, Changhua Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
  1. Dr. Ling-Ling Hsieh, Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C. Tel: +886 0422391647 #7116, e-mail: llhsieh2013{at}gmail.com
  2. Dr. Cheng-Hsien Chen, Surgical Intensive Care Unit, Department of Surgery, Changhua Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C. Tel: +886 933283767, e-mail: picorna{at}gmail.com
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Lenvatinib Suppresses Colorectal Cancer Cell Growth, Migration, and Invasion via Dual-pathway Apoptosis and ERK/STAT3/NF-κB Inactivation
CHING-HSUAN WU, FEI-TING HSU, CHUN-HSIEN CHEN, PEI-EN WANG, HUAI-YI HUANG, LING-LING HSIEH, CHENG-HSIEN CHEN
In Vivo Jan 2026, 40 (1) 264-273; DOI: 10.21873/invivo.14189

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Lenvatinib Suppresses Colorectal Cancer Cell Growth, Migration, and Invasion via Dual-pathway Apoptosis and ERK/STAT3/NF-κB Inactivation
CHING-HSUAN WU, FEI-TING HSU, CHUN-HSIEN CHEN, PEI-EN WANG, HUAI-YI HUANG, LING-LING HSIEH, CHENG-HSIEN CHEN
In Vivo Jan 2026, 40 (1) 264-273; DOI: 10.21873/invivo.14189
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Keywords

  • colorectal cancer
  • lenvatinib
  • apoptosis
  • ERK/STAT3/NF-κB
  • proliferation
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