Table of Contents

Clinical Studies

• Open Access

  Expression and Clinical Significance of Sideroflexin 4 (SFXN4) in Colorectal Cancer

  LEVAR SHAMOUN, JAN DIMBERG, KRISTIN A.F. GEIJERSTAM, ELIN MOLTUBAK, KALLE LANDERHOLM and DICK WÅGSÄTER

  In Vivo November 2025, 39 (6) 3367-3380; DOI: https://doi.org/10.21873/invivo.14134
• Open Access

  A Snapshot from the Italian Clinical Practice Regarding Efficacy and Utility Rate of Perioperative Chemotherapy in Muscle-invasive Bladder Cancer: The RealBLADDER Study

  ELISABETTA GAMBALE, ROBERTA GIORGIONE, UMBERTO BASSO, LUCA GALLI, GIUSEPPE FORNARINI, FRANCESCO ATZORI, SARAH SCAGLIARINI, CRISTINA MASINI, VALENTINA BALDAZZI, FEDERICO SCOLARI, MARINELLA MICOL MELA, MARCO MARUZZO, ISMAELA ANNA VASCOTTO, VIRGINIA ROSSI, DANIELE ROSSINI, GIANDOMENICO ROVIELLO, DANIELE LAVACCHI, SERGIO SERNI, ANDREA MINERVINI, SERENA PILLOZZI and LORENZO ANTONUZZO

  In Vivo November 2025, 39 (6) 3381-3393; DOI: https://doi.org/10.21873/invivo.14135
• Open Access

  Prognostic Role of Bacterial Translocation, Serum Endotoxin, and ZO-1 in Postoperative Infections Following Colorectal Cancer Surgery

  NIKOLAOS BENETATOS, DIMITRA GEORGAKOPOULOU, ANNE-LISE DE LASTIC, DIAMANTO ARETHA, GEORGIOS SKROUBIS, VASILEIOS LEIVADITIS, EFSTRATIOS KOLETSIS, FEVRONIA KOLONITSIOU, ATHANASIA MOUZAKI, IOANNIS MAROULIS and STELIOS F. ASSIMAKOPOULOS

  In Vivo November 2025, 39 (6) 3394-3405; DOI: https://doi.org/10.21873/invivo.14136
• Open Access

  Impact of the Timing of Initial Anamorelin Administration in Advanced Gastrointestinal Cancer With Cancer Cachexia

  DAISUKE YOSHIDA, MAKOTO ISHIMATSU, SHUTO NAKASHIMA, KOUJI NAKANO, SHUNSUKE ISHIDA, HIROKI ORIMOTO, TSUKASA MIYAGAHARA, KAZUHIRO YADA, TOSHIFUMI MATSUMOTO and HIROFUMI KAWANAKA

  In Vivo November 2025, 39 (6) 3406-3411; DOI: https://doi.org/10.21873/invivo.14137
• Open Access

  Tumor Location Is a Significant Predictor of Lymphovascular Invasion in Patients With Small-sized Non-small Cell Lung Cancer

  TAKUMA TSUKIOKA, RYU NAKAJIMA, KYUKWANG CHUNG, SATOSHI OKADA, KAZUYA KISHIMOTO and HIROYUKI KOCHI

  In Vivo November 2025, 39 (6) 3412-3417; DOI: https://doi.org/10.21873/invivo.14138
• Open Access

  Delayed Primary Skin Closure Followed by Single-use Negative-pressure Wound Therapy Is Optimal for Wound Management After Bowel-stoma Reversal

  TAKUMU FUKASAWA, KEN IMAIZUMI, KAZUTOSHI TERASHIMA, HIROYUKI KASAJIMA, NAOE FURUKAWA, KEIICHIRO ITO, TADASHI ODAGIRI, DAISUKE YAMANA, YOSUKE TSURUGA, MINORU UMEHARA, MICHIHIRO KURUSHIMA and KAZUAKI NAKANISHI

  In Vivo November 2025, 39 (6) 3418-3427; DOI: https://doi.org/10.21873/invivo.14139
• Open Access

  Heterogeneity of Tumor Glucose Metabolism in Schwannomas Between Trunk and Extremities: An Imaging Study

  YUTA MIYASHI, HIROMICHI OSHIRO, YOSHIRO YOSHIKAWA, RYO KATSUKI, YASUNORI TOME and KOTARO NISHIDA

  In Vivo November 2025, 39 (6) 3428-3436; DOI: https://doi.org/10.21873/invivo.14140
• Open Access

  In Vivo Probability of Metastases in Levels IV-V in Oral Squamous Cell Carcinoma With a cN0/pN+ Situation in Levels I-III

  LIVIA HAAS, ROBERT ANDREAS MISCHKOWSKI, UTA KNAPE, KAROLINA MARIA KRÓL and ANDREAS SAKKAS

  In Vivo November 2025, 39 (6) 3437-3444; DOI: https://doi.org/10.21873/invivo.14141
• Open Access

  Comparison of the Use of Immune Checkpoint Inhibitor/Tyrosine Kinase Inhibitor and Tyrosine Kinase Inhibitor Alone for Patients With Low Risk Metastatic Renal Cell Carcinoma

  MASAHARU OKI, KOJIRO OHBA, YUTA MUKAE, TSUYOSHI MATSUDA, HIROMI NAKANISHI, KENSUKE MITSUNARI, TOMOHIRO MATSUO, YASUSHI MOCHIZUKI and RYOICHI IMAMURA

  In Vivo November 2025, 39 (6) 3445-3452; DOI: https://doi.org/10.21873/invivo.14142
• Open Access

  Disproportionality Analysis of Gastrointestinal Adverse Events Associated With Trastuzumab Deruxtecan Using the Japanese Adverse Drug Event Report database

  YUKO KANBAYASHI, RISA MORIOKA, KOICHI TAKAYAMA and KEIKO HOSOHATA

  In Vivo November 2025, 39 (6) 3453-3460; DOI: https://doi.org/10.21873/invivo.14143
• Open Access

  Patterns of Recurrence and Malignant Transformation in Sinonasal Papilloma: Implications for Long-term Follow-up

  TAKAYUKI KIMURA, SATORU KOIKE, HISATOMO TAMAKI, KAZUHIRO MIYAMOTO, SHUSUKE IWAMOTO, NORIKO OHIRA, DAISUKE ABE, MITSUO SATO, MUTSUKAZU KITANO, TAKAHIRO WAKASAKI and RYUJI YASUMATSU

  In Vivo November 2025, 39 (6) 3461-3467; DOI: https://doi.org/10.21873/invivo.14144
• Open Access

  Malnutrition in Cancer Patients – An Investigation of Malnutrition and Professional Intervention by Healthcare Professionals in Oncology

  LEA ARMBRUST, JULIA VON GRUNDHERR, STEPHAN METZELDER, IVAYLO VASILEV, VIKTORIA MATHIES and JUTTA HÜBNER

  In Vivo November 2025, 39 (6) 3468-3483; DOI: https://doi.org/10.21873/invivo.14145
• Open Access

  Investigation of the Usefulness of Waveform Classification Analysis of Oxygen Saturation for Sleep Apnea Syndrome

  MIZUKI TAKAYASU, NAOKO KATSURADA, MASATSUGU YAMAMOTO, SHINTARO IZUMI, ASUKA YOSHIZAKI, KANOKO MATSUMURA and TATSUYA NAGANO

  In Vivo November 2025, 39 (6) 3484-3490; DOI: https://doi.org/10.21873/invivo.14146
• Open Access

  Preoperative Liver Function as a Predictor of Postoperative Liver Failure in Perihilar Cholangiocarcinoma

  YASUNORI YOSHIMI, SATOKO YORINAGA, TAKEHIRO NOJI, SHINTARO TAKEUCHI, MASATAKA WADA, KIMITAKA TANAKA, AYA MATSUI, YOSHITSUGU NAKANISHI, TOSHIMICHI ASANO and SATOSHI HIRANO

  In Vivo November 2025, 39 (6) 3491-3502; DOI: https://doi.org/10.21873/invivo.14147
• Open Access

  Improved Implementation of Tumor Board Decisions: A Retrospective Single Center Observational Study in Germany

  JOHANNA ERNST, KATHARINA ALFTER, ALEXANDER MUSTEA, ANDREE FARIDI, TIM GLOWKA, ULRICH HERRLINGER, SEBASTIAN KOOB, THORE THIESLER, FREDERICK FAR, TORSTEN PIETSCH, ULRIKE ATTENBERGER, NICOLE ERNSTMANN, JENNIFER LANDSBERG, MARKUS ESSLER, MANUEL RITTER, STEFAN HAUSER, GEORG FELDMANN, FRANZ GEORG BAUERNFEIND, STEFAN ARETZ, MARIA GONZALEZ-CARMONA, MATTHIAS SCHMID, AMIT SHARMA and INGO G. H. SCHMIDT-WOLF

  In Vivo November 2025, 39 (6) 3503-3515; DOI: https://doi.org/10.21873/invivo.14148
• Open Access

  Best Practices for Instagram in Medical Education: A Study With Randomized Post Designs

  REBECCA I. WURM-KUCZERA, JULIA F.L. KOENIG and JUDITH BUENTZEL

  In Vivo November 2025, 39 (6) 3516-3521; DOI: https://doi.org/10.21873/invivo.14149
• Open Access

  O-Linked N-Acetylglucosamine Epitope H Expression in Placentas of Pregnancies Complicated With Fetal Growth Restriction: A Case–Control Immunochemistry Study

  AGAPI KARKABOUNA, ATHINA A. SAMARA, KONSTANTINA ZACHAROULI, MARIA IOANNOU, ANTONIOS GARAS, ALEXANDROS DAPONTE and SOTIRIOS SOTIRIOU

  In Vivo November 2025, 39 (6) 3522-3528; DOI: https://doi.org/10.21873/invivo.14150
• Open Access

  Comparison of Survival Outcomes and Toxicities Between Volumetric-modulated Arc Therapy and Conventional Radiotherapy in Early Glottic Cancer

  HYEON KANG KOH, YOUNGHEE PARK, TAERYOOL KOO, KWANG-HO CHEONG, ME YEON LEE, HAE JIN PARK, KYOUNG JU KIM, SOAH PARK, TAEJIN HAN, SEI-KWON KANG, BORAM HA, JAI-WOONG YOON, ME YOUNG KIM and HOONSIK BAE

  In Vivo November 2025, 39 (6) 3529-3538; DOI: https://doi.org/10.21873/invivo.14151
• Open Access

  Clinicopathological Characteristics of Atypical Polypoid Adenomyoma of the Uterus in Association With Endometrial Atypical Hyperplasia and Endometrioid Carcinoma

  TAEYEONG KIM, YOON AH CHO and HYUN-SOO KIM

  In Vivo November 2025, 39 (6) 3539-3551; DOI: https://doi.org/10.21873/invivo.14152
• Open Access

  Up-front Hypofractionated Radiotherapy Before Third-Generation Chemotherapy in Node-positive Breast Cancer: A Retrospective Comparative Study

  ANTONIETTA MONTAGNA, ILARIA BENEVENTO, BARBARA D’ANDREA, ANTONELLA BIANCULLI, RAFFAELE TUCCIARIELLO, VITO METALLO, IRENE SCHIRÒ, TERESA VIRGILIO, ANNA ZECCOLA and GRAZIA LAZZARI

  In Vivo November 2025, 39 (6) 3552-3562; DOI: https://doi.org/10.21873/invivo.14153
• Open Access

  Pharmacogenomic Insights: The Role of CYP2D6 Allelic Variants in Drug Metabolism Among COVID-19 Patients With Comorbidities

  MERT ÖZEN, ALTEN OSKAY, İBRAHIM TÜRKÇÜER, ATAKAN YILMAZ, MURAT SEYIT, YASEMIN ADALI, VEFA ÇAKMAK and AYLIN KÖSELER

  In Vivo November 2025, 39 (6) 3563-3574; DOI: https://doi.org/10.21873/invivo.14154
• Open Access

  Evaluation of the Effect of Rectal Dilatation on Bowel Function by Sagittal CT Imaging

  KAITO YAMASAWA, HIDEJIRO KAWAHARA, SEIYA FUJII, YUHEI TSUKAZAKI, TOMO MATSUMOTO, TSUYOSHI HIRABAYASHI and NOBUO OMURA

  In Vivo November 2025, 39 (6) 3575-3580; DOI: https://doi.org/10.21873/invivo.14155
• Open Access

  Impact of Multiple Primary Cancers on the Prognosis of Early-stage Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma: A Single-center Retrospective Study

  RYUJI YASUMATSU, DAISUKE ABE, TAKAYUKI KIMURA, SHINICHIRO IWATA, MASAYUKI OCHIAI, SAYUMI KONYA, MAYA KAWAMOTO, MASAHIRO UMEMOTO, SATORU KOIKE, MITSUO SATO, MUTSUKAZU KITANO and TAKAHIRO WAKASAKI

  In Vivo November 2025, 39 (6) 3581-3588; DOI: https://doi.org/10.21873/invivo.14156
• Open Access

  Marked Increase in Zinc Concentration of Ascitic Fluid After Cell-free and Concentrated Ascites Reinfusion Therapy in Patients With Cirrhotic Refractory Ascites: A Retrospective Observational Study

  TADASHI NAMISAKI, AKIHIKO SHIBAMOTO, SATOSHI IWAI, MASAYOSHI TAKAMI, HIROYUKI MASUDA, YUKI TSUJI, YUKIHISA FUJINAGA, HIROAKI TAKAYA, TAKASHI INOUE, SHINYA SATO, KOH KITAGAWA, NORIHISA NISHIMURA, KOSUKE KAJI, AKIRA MITORO, KIYOSHI ASADA and HITOSHI YOSHIJI

  In Vivo November 2025, 39 (6) 3589-3595; DOI: https://doi.org/10.21873/invivo.14157
• Open Access

  Effectiveness of Scalp-cooling Therapy for Preventing Chemotherapy-induced Alopecia in Patients With Breast Cancer: A Prospective Observational Study Focusing on Scalp, Eyebrow, and Eyelash Hair Loss

  TAKAAKI FUJII, KEI ICHIBA, MAYU AOKI, KEIKO TANABE, MISATO OGINO, SAYAKA OBAYASHI and HIROYUKI TAKEI

  In Vivo November 2025, 39 (6) 3596-3601; DOI: https://doi.org/10.21873/invivo.14158
• Open Access

  Loss of ZC3H12A Expression Is Linked to Higher Mortality Risk and Increased Lymphatic Metastasis in Oral Squamous Cell Carcinoma

  SHANG-LUN CHIANG, JIA-JIUN TSAI, YU-NAN HUANG, JENG-WEI LU, SHENG-YUAN HOU, YUN-JUNG TSAI and SHU-HUI LIN

  In Vivo November 2025, 39 (6) 3602-3616; DOI: https://doi.org/10.21873/invivo.14159
• Open Access

  The Prognostic Impact of HER2 Status and Survival Outcomes in Metastatic Triple Negative Breast Cancer

  ALPER TURKEL, ECE BAYDAR, RÜMEYSA ÇOLAK, AHMET EMİN ÖZTÜRK, TEOMAN ŞAKALAR, SİNEM AKBAŞ, HASİBE BİLGE GÜR, EYYÜP ÇAVDAR, MESUT YILMAZ, DEVRİM ÇABUK, FATİH SELÇUKBİRİCİK, İLHAN HACIBEKİROĞLU and MUTLU DOGAN

  In Vivo November 2025, 39 (6) 3617-3625; DOI: https://doi.org/10.21873/invivo.14160
• Open Access

  Anamorelin in Cancer Cachexia: Gut Microbiota Effects and CONUT Score as a Predictor of Response

  SHOGEN BOKU, TOMOYO YASUDA, TATSUKI IKOMA, ERI MATSUMORI, SAWAKO YOSHIUCHI, YOSHIYUKI MATSUO, KOICHIRO HIGASA and TAKAYASU KURATA

  In Vivo November 2025, 39 (6) 3626-3635; DOI: https://doi.org/10.21873/invivo.14161
• Open Access

  Epidemiological Profile of Hepatocellular Carcinoma in Brazil

  REBECA REIS DA ROCHA, MÁRIO RINO MARTINS, LUCIANA WALTER PESSOA DE MELO, ROGÉRIO LUIZ DOS SANTOS, LEURIDAN CAVALCANTE TORRES, LUIZ CLAUDIO SANTOS THULER and GUILHERME JORGE COSTA

  In Vivo November 2025, 39 (6) 3636-3645; DOI: https://doi.org/10.21873/invivo.14162