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Research ArticleExperimental Studies
Open Access

Contribution of Interleukin-4 Promoter Genotypes to Gastric Cancer Risk in Taiwan

CHUN-KAI FU, HSU-TUNG LEE, YA-CHEN YANG, JAW-CHYUN CHEN, MEI-DUE YANG, YUN-CHI WANG, HOU-YU SHIH, CHIA-WEN TSAI, DA-TIAN BAU and WEN-SHIN CHANG
In Vivo July 2025, 39 (4) 1912-1923; DOI: https://doi.org/10.21873/invivo.13990
CHUN-KAI FU
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
2Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.;
3National Defense Medical Center, Taipei, Taiwan, R.O.C.;
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HSU-TUNG LEE
4Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan, R.O.C.;
5Division of Neurosurgical Oncology, Department of Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.;
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YA-CHEN YANG
6Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.;
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JAW-CHYUN CHEN
7Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.;
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MEI-DUE YANG
8Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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YUN-CHI WANG
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
8Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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HOU-YU SHIH
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
8Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHIA-WEN TSAI
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
8Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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DA-TIAN BAU
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
8Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
9Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
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  • For correspondence: 013280{at}tool.caaumed.org.tw
WEN-SHIN CHANG
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
8Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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  • For correspondence: 031002{at}tool.caaumed.org.tw
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Article Information

vol. 39 no. 4 1912-1923
DOI 
https://doi.org/10.21873/invivo.13990
PMID 
40578990

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received March 21, 2025
  • Revision received April 6, 2025
  • Accepted April 7, 2025
  • Published online June 27, 2025.

Copyright & License 
Copyright © 2025 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. CHUN-KAI FU1,2,3,*,
  2. HSU-TUNG LEE4,5,*,
  3. YA-CHEN YANG6,*,
  4. JAW-CHYUN CHEN7,
  5. MEI-DUE YANG8,
  6. YUN-CHI WANG1,8,
  7. HOU-YU SHIH1,8,
  8. CHIA-WEN TSAI1,8,
  9. DA-TIAN BAU1,8,9⇑ and
  10. WEN-SHIN CHANG1,8⇑
  1. 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
  2. 2Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.;
  3. 3National Defense Medical Center, Taipei, Taiwan, R.O.C.;
  4. 4Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan, R.O.C.;
  5. 5Division of Neurosurgical Oncology, Department of Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.;
  6. 6Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.;
  7. 7Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.;
  8. 8Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
  9. 9Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
  1. Wen-Shin Chang, Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, R.O.C. Tel: +886 422053366 Ext. 5805, e-mail: 031002{at}tool.caaumed.org.tw (WSC)
  2. Da-Tian Bau, Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, R.O.C. Tel: +886 422053366 Ext. 5805, e-mail: 013280{at}tool.caaumed.org.tw (DTB)
  1. ↵* These Authors contributed equally to this study.

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Contribution of Interleukin-4 Promoter Genotypes to Gastric Cancer Risk in Taiwan
CHUN-KAI FU, HSU-TUNG LEE, YA-CHEN YANG, JAW-CHYUN CHEN, MEI-DUE YANG, YUN-CHI WANG, HOU-YU SHIH, CHIA-WEN TSAI, DA-TIAN BAU, WEN-SHIN CHANG
In Vivo Jul 2025, 39 (4) 1912-1923; DOI: 10.21873/invivo.13990

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Contribution of Interleukin-4 Promoter Genotypes to Gastric Cancer Risk in Taiwan
CHUN-KAI FU, HSU-TUNG LEE, YA-CHEN YANG, JAW-CHYUN CHEN, MEI-DUE YANG, YUN-CHI WANG, HOU-YU SHIH, CHIA-WEN TSAI, DA-TIAN BAU, WEN-SHIN CHANG
In Vivo Jul 2025, 39 (4) 1912-1923; DOI: 10.21873/invivo.13990
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Keywords

  • Cancer risk
  • Gastric cancer
  • genotype
  • interleukin-4
  • single nucleotide polymorphism
  • Taiwan
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