Preface

The advancement of permanent and biodegradable implants relies on a comprehensive approach that integrates in vivo, in vitro, and in silico characterization to enhance their performance and biocompatibility. This collection of studies explores key aspects of implant development, from surface modifications that improve protein adsorption and osteoblast adhesion to the effects of sandblasting parameters on roughness and wettability, ultimately influencing osseointegration. Investigations into the mechanical and electrochemical behavior of additively manufactured titanium alloys provide valuable insights into fatigue resistance and corrosion performance, while alternative biocompatibility testing methods, such as the chick chorioallantoic membrane model, offer promising strategies for early-stage evaluation. By addressing both fundamental material properties and preclinical assessment methodologies, these studies contribute to the ongoing innovation in implant technology, paving the way for improved clinical outcomes and more sustainable biomaterial testing approaches.

• Copyright © 2025 The Author(s). Published by the International Institute of Anticancer Research.