Factors for Discontinuation of Naldemedine Therapy in a Palliative Ward

Receiver operating characteristic (ROC) curve and the rate of continuation of naldemedine over 14 days. (A) The ROC curve shows the ability of C-reactive protein-to-albumin ratio (CAR) to predict discontinuation of naldemedine therapy. The cut-off value of CAR was 0.888, with sensitivity of 0.818 and specificity of 0.534. (B) Kaplan-Meier curve indicating the rate of naldemedine continuation for 14 days. In patients with CAR<0.888, naldemedine was administered for an average of 13.2 (95% confidence interval=12.5-14.0) days whilst in patients with CAR≥0.888, administration continued for 11.6 (95% confidence interval=10.5-12.6) days. *Significantly different at p<0.05 (log-rank test).